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Here we investigated the effects of GADD34 on acrolein-induced lung injury. The intranasal exposure of acrolein induced the expression of GADD34, developing the pulmonary damage with inflammation and increase of reactive oxygen species (ROS). Conversely, the integrality of pulmonary structure was preserved and the generation of ROS was reduced in GADD34-knockout mice. Acrolein-induced phosphorylation of eIF2<jats:italic>\u03b1<\/jats:italic>in GADD34-knockout epithelial cells by shRNA protected cell death by reducing misfolded protein-caused oxidative stress. These data indicate that GADD34 participates in the development of acrolein-induced lung injury.<\/jats:p>","DOI":"10.1155\/2015\/170309","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T16:01:01Z","timestamp":1425398461000},"page":"1-15","source":"Crossref","is-referenced-by-count":30,"title":["Enhancement of the Acrolein-Induced Production of Reactive Oxygen Species and Lung Injury by GADD34"],"prefix":"10.1155","volume":"2015","author":[{"given":"Yang","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Immunology, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan"},{"name":"Department of Immunology, Norman Bethune College of Medicine, Jilin University, Changchun 130021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachiko","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Immunology, Nagoya University Graduate School of Medicine, Nagoya 466-8550, 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