{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T19:51:03Z","timestamp":1648756263717},"reference-count":24,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. To evaluate the effects of corneal glyceraldehyde CXL on the rabbit bullous keratopathy models established by descemetorhexis.<jats:italic>Methods<\/jats:italic>. Fifteen rabbits were randomly divided into five groups. Group A (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>3<\/mml:mn><\/mml:math>) is the control group. The right eyes of animals in Groups B,C, D, and E (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>3<\/mml:mn><\/mml:math>, resp.) were suffered with descemetorhexis procedures. From the 8th day to the 14th day postoperatively, the right eyes in Groups C and D were instilled with hyperosmolar drops and glyceraldehyde drops, respectively; the right eyes in Group E were instilled with both hyperosmolar drops and glyceraldehyde drops. Central corneal thickness (CCT), corneal transparency score, and histopathological analysis were applied on the eyes in each group.<jats:italic>Results<\/jats:italic>. Compared with Group A, statistically significant increase in CCT and corneal transparency score was found in Groups B, C, D, and E at 7\u2009d postoperatively (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>) and in Groups C, D, and E at 14\u2009d postoperatively (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>).<jats:italic>Conclusion<\/jats:italic>. Chemical CXL technique using glyceraldehyde improved the CCT and corneal transparency of the rabbit bullous keratopathy models. Topical instillation with glyceraldehyde and hyperosmolar solutions seems to be a good choice for the bullous keratopathy treatment.<\/jats:p>","DOI":"10.1155\/2015\/171690","type":"journal-article","created":{"date-parts":[[2015,10,5]],"date-time":"2015-10-05T21:02:41Z","timestamp":1444078961000},"page":"1-5","source":"Crossref","is-referenced-by-count":1,"title":["Effect of Glyceraldehyde Cross-Linking on a Rabbit Bullous Keratopathy Model"],"prefix":"10.1155","volume":"2015","author":[{"given":"Mengmeng","family":"Wang","sequence":"first","affiliation":[{"name":"Hebei Provincial Eye Hospital, Hebei Provincial Ophthalmology Key Lab, Hebei Provincial Institute of Ophthalmology, Xingtai, Hebei 054001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1097\/ico.0b013e3182014821"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/s0886-3350(02)01984-3"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/0039-6257(93)90099-S"},{"issue":"1","key":"4","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1177\/112067210501500103","volume":"15","year":"2005","journal-title":"European Journal of Ophthalmology"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9394(02)02220-1"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/s0886-3350(03)00407-3"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2003.11.032"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.07.038"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1159\/000187630"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-13703"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-200404000-00011"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2009.07.041"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2013.02.008"},{"issue":"3","key":"14","first-page":"149","volume":"13","year":"1987","journal-title":"Contact Lens Association of Ophthalmologists Journal"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2006.11.015"},{"issue":"7","key":"16","doi-asserted-by":"crossref","first-page":"S730","DOI":"10.3928\/1081597X-20080901-17","volume":"24","year":"2008","journal-title":"Journal of Refractive Surgery"},{"key":"17","first-page":"1222","volume":"19","year":"2013","journal-title":"Molecular Vision"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1080\/02713680701530589"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-010-1504-9"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.0412-4081.2014.01.013"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2007.01156.x"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2007.12.030"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1097\/ico.0b013e31824d6fe3"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/869015"}],"container-title":["Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/joph\/2015\/171690.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/joph\/2015\/171690.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/joph\/2015\/171690.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,31]],"date-time":"2019-08-31T07:20:50Z","timestamp":1567236050000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/joph\/2015\/171690\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":24,"alternative-id":["171690","171690"],"URL":"https:\/\/doi.org\/10.1155\/2015\/171690","relation":{},"ISSN":["2090-004X","2090-0058"],"issn-type":[{"value":"2090-004X","type":"print"},{"value":"2090-0058","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}