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The interaction between airway epithelium and inflammatory mediators plays a key role in the pathogenesis of asthma. <jats:italic>In vitro<\/jats:italic> studies evaluated the inhibitory effects of 3\u2010(2,5\u2010dimethoxyphenyl)\u20101\u2010(5\u2010methylfuran\u20102\u2010yl)prop\u20102\u2010en\u20101\u2010one (DMPF\u20101), a synthetic chalcone analogue, upon inflammation in the A549 lung epithelial cell line. DMPF\u20101 selectively inhibited TNF\u2010<jats:italic>\u03b1<\/jats:italic>\u2010stimulated CC chemokine secretion (RANTES, eotaxin\u20101, and MCP\u20101) without any effect upon CXC chemokine (GRO\u2010<jats:italic>\u03b1<\/jats:italic> and IL\u20108) secretion. Western blot analysis further demonstrated that the inhibitory activity resulted from disruption of p65NF\u2010<jats:italic>\u03ba<\/jats:italic>B nuclear translocation without any effects on the mitogen\u2010activated protein kinase (MAPK) pathway. Treatment of ovalbumin\u2010sensitized and ovalbumin\u2010challenged BALB\/c mice with DMPF\u20101 (0.2\u2013100\u2009mg\/kg) demonstrated significant reduction in the secretion and gene expression of CC chemokines (RANTES, eotaxin\u20101, and MCP\u20101) and Th2 cytokines (IL\u20104, IL\u20105, and IL\u201013). Furthermore, DMPF\u20101 treatment inhibited eosinophilia, goblet cell hyperplasia, peripheral blood total IgE, and airway hyperresponsiveness in ovalbumin\u2010sensitized and ovalbumin\u2010challenged mice. In conclusion, these findings demonstrate the potential of DMPF\u20101, a nonsteroidal compound, as an antiasthmatic agent for further pharmacological evaluation.<\/jats:p>","DOI":"10.1155\/2015\/176926","type":"journal-article","created":{"date-parts":[[2015,8,2]],"date-time":"2015-08-02T21:01:25Z","timestamp":1438549285000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Inhibition of Epithelial CC\u2010Family Chemokine Synthesis by the Synthetic Chalcone DMPF\u20101 via Disruption of NF\u2010<i>\u03ba<\/i>B Nuclear Translocation and Suppression of Experimental Asthma in Mice"],"prefix":"10.1155","volume":"2015","author":[{"given":"Revathee","family":"Rajajendram","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9734-0372","authenticated-orcid":false,"given":"Chau Ling","family":"Tham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamad Nadeem","family":"Akhtar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohd Roslan","family":"Sulaiman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daud Ahmad","family":"Israf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,8,2]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2006.00413.x"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200102013440507"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-0100"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.10.047"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2737"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/35100503"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199802123380706"},{"key":"e_1_2_7_8_2","first-page":"1","article-title":"Role of cytokines in pathophysiology of asthma","volume":"5","author":"Mahajan S.","year":"2006","journal-title":"Iranian Journal of Pharmacology and Therapeutics"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-7-125"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.11.7053"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00301.2009"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2011.56"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2006.09.019"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2006.04.025"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.2332\/allergolint.09-OA-0118"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00044-011-9706-1"},{"key":"e_1_2_7_17_2","first-page":"S11","article-title":"The inflammatory response in the pathogenesis of asthma","volume":"111","author":"Ishmael F. 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