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The aim of this study is to characterize the role of dopamine on the cognitive processes that precede movement in a reaction time paradigm in PD. We enrolled 16 newly diagnosed and untreated patients with PD without cognitive impairment or depression and 10 control subjects with essential tremor. They performed multiple-choice reaction time task with the right upper limb and brain<jats:sup>18<\/jats:sup>F-DOPA PET\/CT scan. A significant inverse correlation was highlighted between average reaction time and<jats:sup>18<\/jats:sup>F-DOPA uptake in the left lateral orbitofrontal cortex. No correlations were found between reaction time and PD disease severity or between reaction time and<jats:sup>18<\/jats:sup>F-DOPA uptake in controls. Our study shows that in PD, but not in controls, reaction time is inversely related to the levels of dopamine in the left lateral orbitofrontal cortex. This novel finding underlines the role of dopamine in the lateral orbitofrontal cortex in the early stages of PD, supporting a relation between the compensatory cortical dopamine and movement preparation.<\/jats:p>","DOI":"10.1155\/2015\/180940","type":"journal-article","created":{"date-parts":[[2015,6,11]],"date-time":"2015-06-11T21:40:51Z","timestamp":1434058851000},"page":"1-7","source":"Crossref","is-referenced-by-count":5,"title":["Orbitofrontal<sup><b>18<\/b><\/sup>F-DOPA Uptake and Movement Preparation in Parkinson\u2019s Disease"],"prefix":"10.1155","volume":"2015","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0620-7654","authenticated-orcid":true,"given":"Lucio","family":"Marinelli","sequence":"first","affiliation":[{"name":"Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Largo Daneo 3, 16132 Genoa, 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