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This is, presumably, aimed at fine-tuning adaptive immune responses according to local signals. Reprograming of cell phenotype is made possible by changes in activation of master transcription factors, employing epigenetic modifications that preserve a flexible mode, permitting a shift between activation and silencing of genes. The acute phase response represents an example of peripheral changes that are critical in modulating T cell responses.<jats:italic>\u03b1<\/jats:italic>1-antitrypsin (AAT) belongs to the acute phase responses and has recently surfaced as a tolerogenic agent in the context of adaptive immune responses. Nonetheless, AAT does not inhibit T cell responses, nor does it shutdown inflammation per se; rather, it appears that AAT targets non-T cell immunocytes towards changing the cytokine environment of T cells, thus promoting a regulatory T cell profile. The present review focuses on this intriguing two-way communication between innate and adaptive entities, a crosstalk that holds important implications on potential therapies for a multitude of immune disorders.<\/jats:p>","DOI":"10.1155\/2015\/184574","type":"journal-article","created":{"date-parts":[[2015,10,25]],"date-time":"2015-10-25T21:01:40Z","timestamp":1445806900000},"page":"1-14","source":"Crossref","is-referenced-by-count":20,"title":["T Helper Subsets, Peripheral Plasticity, and the Acute Phase Protein,<i>\u03b1<\/i>1-Antitrypsin"],"prefix":"10.1155","volume":"2015","author":[{"given":"Boris M.","family":"Baranovski","sequence":"first","affiliation":[{"name":"Department of Clinical Biochemistry & Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, 84101 Be\u2019er Sheva, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella S.","family":"Freixo-Lima","sequence":"additional","affiliation":[{"name":"Department of Clinical 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