{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:57:18Z","timestamp":1787500638081,"version":"build-2736575974"},"reference-count":56,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Research Project of Health Bureau of Chongqing","award":["2013-1-031"],"award-info":[{"award-number":["2013-1-031"]}]},{"name":"Research Project of Health Bureau of Chongqing","award":["cstc2014yykfB10010"],"award-info":[{"award-number":["cstc2014yykfB10010"]}]},{"name":"Chongqing Science & Technology Commission","award":["2013-1-031"],"award-info":[{"award-number":["2013-1-031"]}]},{"name":"Chongqing Science & Technology Commission","award":["cstc2014yykfB10010"],"award-info":[{"award-number":["cstc2014yykfB10010"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>\n                    The aim of the study was to determine whether or not dexmedetomidine- (DEX-) based intravenous infusion in dental implantation can provide better sedation and postoperative analgesia via suppressing postoperative inflammation and oxidative stress. Sixty patients were randomly assigned to receive either DEX (group D) or midazolam (group M). Recorded variables were vital sign (SBP\/HR\/RPP\/SpO\n                    <jats:sub>2<\/jats:sub>\n                    \/RR), visual analogue scale (VAS) pain scores, and observer\u2019s assessment of alertness\/sedation scale (OAAS) scores. The plasma levels of interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-\n                    <jats:italic>\u03b1<\/jats:italic>\n                    ), antioxidant superoxide dismutase (SOD), and the lipid peroxidation product malondialdehyde (MDA) were detected at baseline and after 2, 4, and 24\u2009h of drug administration. The VAS pain scores and OAAS scores were significantly lower for patients in group D compared to group M. The plasma levels of TNF-\n                    <jats:italic>\u03b1<\/jats:italic>\n                    , IL-6, and MDA were significantly lower in group D patients than those in group M at 2\u2009h and 4\u2009h. In group M, SOD levels decreased as compared to group D at 2\u2009h and 4\u2009h. The plasma levels of TNF-\n                    <jats:italic>\u03b1<\/jats:italic>\n                    , IL-6, and MDA were positively correlated with VAS pain scores while SOD negatively correlated with VAS pain scores. Therefore, DEX appears to provide better sedation during office-based artificial tooth implantation. DEX offers better postoperative analgesia via anti-inflammatory and antioxidation pathway.\n                  <\/jats:p>","DOI":"10.1155\/2015\/186736","type":"journal-article","created":{"date-parts":[[2015,6,15]],"date-time":"2015-06-15T17:01:33Z","timestamp":1434387693000},"page":"1-11","source":"Crossref","is-referenced-by-count":37,"title":["Dexmedetomidine Analgesia Effects in Patients Undergoing Dental Implant Surgery and Its Impact on Postoperative Inflammatory and Oxidative Stress"],"prefix":"10.1155","volume":"2015","author":[{"given":"Sisi","family":"Li","sequence":"first","affiliation":[{"name":"Department of Anesthesia, Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences, Stomatology Hospital of Chongqing Medical University, No. 426 Songshibeilu, Yubei District, Chongqing 401146, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, Chongqing Key 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