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Due to clinical and pathophysiologic similarities giving a crucial role to the multifunctional cytokine interleukin\u20101, the concept of autoinflammation has been expanded to include nonhereditary collagen\u2010like diseases, idiopathic inflammatory diseases, and metabolic diseases. As more patients are reported to have clinical features of autoinflammation and autoimmunity, the boundary between these two pathologic ends is becoming blurred. An overview of monogenic autoinflammatory disorders, PFAPA syndrome, rheumatoid arthritis, type 2 diabetes mellitus, uveitis, pericarditis, Beh\u00e7et\u2019s disease, gout, Sj\u00f6gren\u2019s syndrome, interstitial lung diseases, and Still\u2019s disease is presented to highlight the fundamental points that interleukin\u20101 displays in the cryptic interplay between innate and adaptive immune systems.<\/jats:p>","DOI":"10.1155\/2015\/194864","type":"journal-article","created":{"date-parts":[[2015,2,16]],"date-time":"2015-02-16T21:02:10Z","timestamp":1424120530000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":82,"title":["Interleukin\u20101 as a Common Denominator from Autoinflammatory to Autoimmune Disorders: Premises, Perils, and 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