{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T06:30:13Z","timestamp":1771655413979,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,1,14]],"date-time":"2015-01-14T00:00:00Z","timestamp":1421193600000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:p>ADAMTS\u20107 has been reported to exaggerate cartilage degeneration and to be associated with TNF\u2010<jats:italic>\u03b1<\/jats:italic> and NF\u2010<jats:italic>\u03ba<\/jats:italic>B signaling pathway. In this study we compared the expression of ADAMTS\u20107, TNF\u2010<jats:italic>\u03b1<\/jats:italic>, and Phospho\u2010NF\u2010<jats:italic>\u03ba<\/jats:italic>B in patients with femoral neck fracture (FNF) and osteonecrosis of femoral head (ONFH) at different stages. We found that expression of ADAMTS\u20107, TNF\u2010<jats:italic>\u03b1<\/jats:italic>, and Phospho\u2010NF\u2010<jats:italic>\u03ba<\/jats:italic>B was significantly upregulated in ONFH patients\u2019 articular cartilage and related to the pathogenesis of ONFH. Thus we conclude that ADAMTS\u20107 level appears to be positively associated with expression of TNF\u2010<jats:italic>\u03b1<\/jats:italic> and Phospho\u2010NF\u2010<jats:italic>\u03ba<\/jats:italic>B P65 in cartilage, which may imply its association with cartilage destruction of ONFH.<\/jats:p>","DOI":"10.1155\/2015\/196702","type":"journal-article","created":{"date-parts":[[2015,1,14]],"date-time":"2015-01-14T21:00:42Z","timestamp":1421269242000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["ADAMTS\u20107 Exhibits Elevated Expression in Cartilage of Osteonecrosis of Femoral Head and Has a Positive Correlation with TNF\u2010<i>\u03b1<\/i> and NF\u2010<i>\u03ba<\/i>B P65"],"prefix":"10.1155","volume":"2015","author":[{"given":"Jing-kun","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun-peng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying-jun","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuai-shuai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan-qiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Nie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,1,14]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-197511000-00028"},{"key":"e_1_2_8_2_2","first-page":"144","article-title":"Alcoholism associated ischemic necrosis of the femoral head. 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