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effect in experimental and clinical studies. However, it was reported that MeCbl had no effect on treating lumbar spinal stenosis induced pain. Thus, the effects of short-term and long-term administration of MeCbl were examined in the chronic compression of dorsal root ganglion (CCD) model. We found that mechanical allodynia was significantly inhibited by a continuous application of high dose and a single treatment of a super high dose of MeCbl. Little is known about mechanisms underlying the analgesia of MeCbl. We examined the effect of MeCbl on the spontaneous activity (SA), the excitability, and hyperpolarization-activated nonselective cation ion current in compressed medium-sized dorsal root ganglion (DRG) neurons using extracellular single fiber recording<jats:italic>in vivo<\/jats:italic>and whole-cell patch clamp<jats:italic>in vitro<\/jats:italic>. We found that MeCbl significantly inhibited the SA of A-type sensory neurons in a dose-dependent manner and inhibited the excitability of medium-sized DRG neurons. In addition, MeCbl also decreased<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:msub><mml:mrow><mml:mi>I<\/mml:mi><\/mml:mrow><mml:mrow><mml:mi>h<\/mml:mi><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math>current density in injured medium-sized DRG neurons. Our results proved that MeCbl might exert an analgesic effect through the inhibition<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:msub><mml:mrow><mml:mi>I<\/mml:mi><\/mml:mrow><mml:mrow><mml:mi>h<\/mml:mi><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math>current and then might inhibit the hyperexcitability of primary sensory neurons under neuropathic pain state.<\/jats:p>","DOI":"10.1155\/2015\/197392","type":"journal-article","created":{"date-parts":[[2015,5,27]],"date-time":"2015-05-27T02:32:58Z","timestamp":1432693978000},"page":"1-13","source":"Crossref","is-referenced-by-count":15,"title":["Inhibition of Hyperpolarization-Activated Cation Current in Medium-Sized DRG Neurons Contributed to the Antiallodynic Effect of Methylcobalamin in the Rat of a Chronic Compression of the DRG"],"prefix":"10.1155","volume":"2015","author":[{"given":"Ming","family":"Zhang","sequence":"first","affiliation":[{"name":"Institute of Neurosciences, the Fourth 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