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The most important of these is the hepatorenal syndrome, a functional renal impairment due to circulatory and neurohormonal abnormalities that underpin cirrhosis. It is one of the most severe complications of cirrhosis with survival often measured in weeks to months. A variety of treatment options exist with early diagnosis and appropriate treatment providing the best hope for cure. This paper provides a comprehensive and up-to-date review of hepatorenal syndrome and lays out the topic according to the following sections: pathophysiology, historical developments, diagnostic criteria and limitations, epidemiology, precipitating factors, predictors, clinical and laboratory findings, prognosis, treatment options, prophylaxis, and conclusion.<\/jats:p>","DOI":"10.1155\/2015\/207012","type":"journal-article","created":{"date-parts":[[2015,1,12]],"date-time":"2015-01-12T22:26:20Z","timestamp":1421101580000},"page":"1-11","source":"Crossref","is-referenced-by-count":37,"title":["Hepatorenal Syndrome: Aetiology, Diagnosis, and Treatment"],"prefix":"10.1155","volume":"2015","author":[{"given":"G.","family":"Low","sequence":"first","affiliation":[{"name":"Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK"},{"name":"University of Alberta, Edmonton, AB, Canada T6G 2B7"},{"name":"University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, P.O. 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