{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:45:54Z","timestamp":1753886754574,"version":"3.41.2"},"reference-count":59,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,5,7]],"date-time":"2015-05-07T00:00:00Z","timestamp":1430956800000},"content-version":"vor","delay-in-days":126,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:p>The present study aimed to evaluate the expression of CD80 and CD18 in subpopulations of peripheral blood leukocytes and oxidative kidney damage in rats with nephrotic syndrome (NS) induced by doxorubicin (Dox) in comparison to control animals at different time points. Male adult Wistar rats were submitted to 24\u2010hour urine and blood collection for biochemical and immunological analysis at 7, 14, 21, and 28 days after Dox injection. After euthanasia, the kidneys were removed for histological analysis and the evaluation of oxidative stress. The phenotypic characterization of leukocytes was performed using flow cytometry. Dox\u2010injected animals exhibited increased CD18 expression in cytotoxic T lymphocytes, NK cells, and monocytes and high CD80 expression in monocytes. Kidney oxidative damage was positively correlated with CD80 expression in monocytes and serum levels of creatinine. These results suggest that phagocytic and cytotoxic cells are preferentially recruited to the tissue injury site, which may contribute to kidney dysfunction in this animal model of NS. The blockade of integrin and costimulatory molecules may provide new therapeutic opportunities for NS.<\/jats:p>","DOI":"10.1155\/2015\/209764","type":"journal-article","created":{"date-parts":[[2015,5,7]],"date-time":"2015-05-07T21:21:08Z","timestamp":1431033668000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Increased Migratory and Activation Cell Markers of Peripheral Blood Lymphocytes in an Experimental Model of Nephrotic Syndrome"],"prefix":"10.1155","volume":"2015","author":[{"given":"Wagner de F\u00e1tima","family":"Pereira","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo Eust\u00e1quio Alvim","family":"Brito-Melo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00e1udia Martins","family":"Carneiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirceu de Sousa","family":"Melo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karine Beatriz","family":"Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e1bio Louren\u00e7o Tadeu","family":"Guimar\u00e3es","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Etel","family":"Rocha-Vieira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c9rica Leandro Marciano","family":"Vieira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Cristina","family":"Sim\u00f5es e Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,5,7]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejmra1106556"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2001.059003975.x"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2000.00342.x"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2009060592"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002275"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-010-1507-0"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-009-1305-8"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/13.8.1975"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12291-010-0017-y"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2369-13-14"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1797.2006.00592.x"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2002.32769"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/bf02698008"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.3109\/08860229809045089"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V84.5.1402.1402"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.1996.d01-785.x"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V641143"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0955-0674(97)80117-2"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90337-9"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1177\/10454411970080040201"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-011-1938-2"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1797.2010.01383.x"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.4142\/jvs.2003.4.2.129"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1999.00529.x"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1681\/asn.2006060622"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-011-2211-x"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.1159\/000178762"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1681\/asn.2007111205"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfl413"},{"key":"e_1_2_8_30_2","first-page":"16","article-title":"Adriamycin-induced nephrotic syndrome in rats: sequence of pathologic events","volume":"46","author":"Bertani T.","year":"1982","journal-title":"Laboratory Investigation"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1999.055003890.x"},{"key":"e_1_2_8_32_2","doi-asserted-by":"publisher","DOI":"10.1159\/000188473"},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(00)00111-1"},{"key":"e_1_2_8_34_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci114957"},{"key":"e_1_2_8_35_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.03098"},{"key":"e_1_2_8_36_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.129.4.1143"},{"key":"e_1_2_8_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80682-2"},{"key":"e_1_2_8_38_2","first-page":"1177","article-title":"Comparative pharmacokinetics of daunomycin and adriamycin in several animal species","volume":"32","author":"Yesair D. W.","year":"1972","journal-title":"Cancer Research"},{"key":"e_1_2_8_39_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1797.2010.01383.x"},{"key":"e_1_2_8_40_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-015-0813-1"},{"key":"e_1_2_8_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1991.63"},{"key":"e_1_2_8_42_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.00664.x"},{"key":"e_1_2_8_43_2","doi-asserted-by":"publisher","DOI":"10.1681\/asn.2009060592"},{"key":"e_1_2_8_44_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2010.04160.x"},{"key":"e_1_2_8_45_2","doi-asserted-by":"publisher","DOI":"10.3109\/10715768909087942"},{"key":"e_1_2_8_46_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.66038.x"},{"key":"e_1_2_8_47_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.00323.x"},{"key":"e_1_2_8_48_2","doi-asserted-by":"publisher","DOI":"10.1159\/000071284"},{"key":"e_1_2_8_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1991.293"},{"key":"e_1_2_8_50_2","first-page":"581","article-title":"Evaluation of T lymphocyte subpopulations in children with nephrotic syndrome","volume":"52","author":"Herrod H.","year":"1983","journal-title":"Clinical & Experimental Immunology"},{"key":"e_1_2_8_51_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2001.059003941.x"},{"key":"e_1_2_8_52_2","doi-asserted-by":"publisher","DOI":"10.1006\/clin.1996.0073"},{"key":"e_1_2_8_53_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.00436.x"},{"key":"e_1_2_8_54_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.163.8.4207"},{"key":"e_1_2_8_55_2","doi-asserted-by":"publisher","DOI":"10.1088\/0953-8984\/22\/19\/194117"},{"key":"e_1_2_8_56_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.128.4.661"},{"key":"e_1_2_8_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0702328"},{"key":"e_1_2_8_58_2","first-page":"583","article-title":"The effect of isoflurane on neutrophil selectin and \u03b22-integrin activation in vitro","volume":"95","author":"De Rossi L. W.","year":"2002","journal-title":"Anesthesia and Analgesia"},{"key":"e_1_2_8_59_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-013-0672-6"}],"container-title":["Mediators of Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2015\/209764.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2015\/209764.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2015\/209764","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T21:28:03Z","timestamp":1722893283000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2015\/209764"}},"subtitle":[],"editor":[{"given":"Ronald","family":"Gladue","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":59,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1155\/2015\/209764"],"URL":"https:\/\/doi.org\/10.1155\/2015\/209764","archive":["Portico"],"relation":{},"ISSN":["0962-9351","1466-1861"],"issn-type":[{"type":"print","value":"0962-9351"},{"type":"electronic","value":"1466-1861"}],"subject":[],"published":{"date-parts":[[2015,1]]},"assertion":[{"value":"2015-03-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-04-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-05-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"209764"}}