{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T19:43:17Z","timestamp":1773430997941,"version":"3.50.1"},"reference-count":50,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"crossref","award":["CZ.1.05\/1.1.00\/02.0123"],"award-info":[{"award-number":["CZ.1.05\/1.1.00\/02.0123"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p><jats:italic>Aim<\/jats:italic>. The purpose of this study is to determine the association between eotaxin 426 C\/T, \u2212384 A\/G, 67 G\/A, eNOS \u2212786 T\/C, 4 a\/b, and MMP-13 rs640198 G\/T and prognosis of patients with known CAD.<jats:italic>Methods<\/jats:italic>. From total of 1161 patients referred to coronary angiography, 532 patients with angiographically confirmed CAD were selected. Their long-term outcome was followed up using hospital database. Subsequent events were assessed in this study: death or combined endpoint-myocardial infarction, unstable angina pectoris, revascularization, heart failure hospitalization, and cardioverter-defibrillator implantation.<jats:italic>Results<\/jats:italic>. The multivariate Cox regression model identified age, smoking, and 3-vessel disease as significant predictors of all-cause death. Further analysis showed that eotaxin 67 G\/A (GA + AA versus GG) and eotaxin \u2212384 A\/G (GG versus GA + AA) were significant independent prognostic factors when added into the model: HR (95% CI) 2.81 (1.35\u20135.85),<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.006<\/mml:mn><\/mml:math>; HR (95% CI) 2.63 (1.19\u20135.83),<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.017<\/mml:mn><\/mml:math>; eotaxin \u2212384 A\/G was significantly associated with the event-free survival, but it did not provide the prognostic information above the effect of two- or three-vessel disease.<jats:italic>Conclusion<\/jats:italic>. The A allele in eotaxin 67 G\/A polymorphism is associated with worse survival in CAD patients.<\/jats:p>","DOI":"10.1155\/2015\/232048","type":"journal-article","created":{"date-parts":[[2015,9,30]],"date-time":"2015-09-30T21:22:22Z","timestamp":1443648142000},"page":"1-7","source":"Crossref","is-referenced-by-count":6,"title":["The Relation between eNOS \u2212786 C\/T, 4 a\/b, MMP-13 rs640198 G\/T, Eotaxin 426 C\/T, \u2212384 A\/G, and 67 G\/A Polymorphisms and Long-Term Outcome in Patients with Coronary Artery Disease"],"prefix":"10.1155","volume":"2015","author":[{"given":"Vladim\u00edr","family":"Kincl","sequence":"first","affiliation":[{"name":"Department of Internal Medicine\/Cardioangiology and ICRC, St. Anne\u2019s University Hospital, Faculty of Medicine, Masaryk University, Peka\u0159sk\u00e1 53, 656 91 Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"M\u00e1chal","sequence":"additional","affiliation":[{"name":"Department 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