{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:48:37Z","timestamp":1787017717924,"version":"build-2736575974"},"reference-count":43,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>\n                    <jats:italic>Objective<\/jats:italic>\n                    . To evaluate the cutaneous and the inner ear tolerance of bioactive glass S53P4 when used in the mastoid and epitympanic obliteration for chronic otitis surgery.\n                    <jats:italic>Material and Methods<\/jats:italic>\n                    . Forty-one cases have been included in this prospective study. Cutaneous tolerance was clinically evaluated 1 week, 1 month, and 3 months after surgery with a physical examination of the retroauricular and external auditory canal (EAC) skin and the presence of otalgia; the inner ear tolerance was assessed by bone-conduction hearing threshold 1 day after surgery and by the presence of vertigo or imbalance.\n                    <jats:italic>Results<\/jats:italic>\n                    . All surgeries but 1 were uneventful: all patients maintained the preoperative bone-conduction hearing threshold except for one case in which the round window membrane was opened during the dissection of the cholesteatoma in the hypotympanum and this led to a dead ear. No dizziness or vertigo was reported. Three months after surgery, healing was achieved in all cases with a healthy painless skin. No cases of revision surgery for removal of the granules occurred in this study.\n                    <jats:italic>Conclusion<\/jats:italic>\n                    . The bioactive glass S53P4 is a well-tolerated biomaterial for primary or revision chronic otitis surgery, as shown by the local skin reaction which lasted less than 3 months and by the absence of labyrinthine complications.\n                  <\/jats:p>","DOI":"10.1155\/2015\/242319","type":"journal-article","created":{"date-parts":[[2015,10,4]],"date-time":"2015-10-04T17:04:24Z","timestamp":1443978264000},"page":"1-6","source":"Crossref","is-referenced-by-count":25,"title":["Cutaneous and Labyrinthine Tolerance of Bioactive Glass S53P4 in Mastoid and Epitympanic Obliteration Surgery: Prospective Clinical Study"],"prefix":"10.1155","volume":"2015","author":[{"given":"Daniele","family":"Bernardeschi","sequence":"first","affiliation":[{"name":"AP-HP, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, Service d\u2019Oto-Rhino-Laryngologie, D\u00e9partement d\u2019Otologie, Implants Auditifs et Chirurgie de Base du Cr\u00e2ne, 75013 Paris, France"},{"name":"Sorbonne Universit\u00e9s, UPMC Univ Paris 06, 75005 Paris, France"},{"name":"Inserm UMR-S 1159, \u201cR\u00e9habilitation Chirurgicale Mini-Invasive et Robotis\u00e9e de l\u2019Audition\u201d, 75018 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4635-0658","authenticated-orcid":true,"given":"Yann","family":"Nguyen","sequence":"additional","affiliation":[{"name":"AP-HP, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, Service d\u2019Oto-Rhino-Laryngologie, D\u00e9partement d\u2019Otologie, Implants Auditifs et Chirurgie de Base du Cr\u00e2ne, 75013 Paris, France"},{"name":"Sorbonne Universit\u00e9s, UPMC Univ Paris 06, 75005 Paris, France"},{"name":"Inserm UMR-S 1159, \u201cR\u00e9habilitation Chirurgicale Mini-Invasive et Robotis\u00e9e de l\u2019Audition\u201d, 75018 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5244-2423","authenticated-orcid":true,"given":"Francesca Yoshie","family":"Russo","sequence":"additional","affiliation":[{"name":"AP-HP, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, Service d\u2019Oto-Rhino-Laryngologie, D\u00e9partement d\u2019Otologie, Implants Auditifs et Chirurgie de Base du Cr\u00e2ne, 75013 Paris, France"},{"name":"Sorbonne Universit\u00e9s, UPMC Univ Paris 06, 75005 Paris, France"},{"name":"Inserm UMR-S 1159, \u201cR\u00e9habilitation Chirurgicale Mini-Invasive et Robotis\u00e9e de l\u2019Audition\u201d, 75018 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Mosnier","sequence":"additional","affiliation":[{"name":"AP-HP, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, Service d\u2019Oto-Rhino-Laryngologie, D\u00e9partement d\u2019Otologie, Implants Auditifs et Chirurgie de Base du Cr\u00e2ne, 75013 Paris, France"},{"name":"Sorbonne Universit\u00e9s, UPMC Univ Paris 06, 75005 Paris, France"},{"name":"Inserm UMR-S 1159, \u201cR\u00e9habilitation Chirurgicale Mini-Invasive et Robotis\u00e9e de l\u2019Audition\u201d, 75018 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyne","family":"Ferrary","sequence":"additional","affiliation":[{"name":"AP-HP, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, Service d\u2019Oto-Rhino-Laryngologie, D\u00e9partement d\u2019Otologie, Implants Auditifs et Chirurgie de Base du Cr\u00e2ne, 75013 Paris, France"},{"name":"Sorbonne Universit\u00e9s, UPMC Univ Paris 06, 75005 Paris, France"},{"name":"Inserm UMR-S 1159, \u201cR\u00e9habilitation Chirurgicale Mini-Invasive et Robotis\u00e9e de l\u2019Audition\u201d, 75018 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Sterkers","sequence":"additional","affiliation":[{"name":"AP-HP, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, Service d\u2019Oto-Rhino-Laryngologie, D\u00e9partement d\u2019Otologie, Implants Auditifs et Chirurgie de Base du Cr\u00e2ne, 75013 Paris, France"},{"name":"Sorbonne Universit\u00e9s, UPMC Univ Paris 06, 75005 Paris, France"},{"name":"Inserm UMR-S 1159, \u201cR\u00e9habilitation Chirurgicale Mini-Invasive et Robotis\u00e9e de l\u2019Audition\u201d, 75018 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","year":"1993"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6093253"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/s0142-9612(99)00181-7"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4636(199704)35:1&lt;9::AID-JBM2>3.0.CO;2-S"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1007\/bf00705283"},{"issue":"2","key":"6","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1177\/145749690609500204","volume":"95","year":"2006","journal-title":"Scandinavian Journal of Surgery"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1007\/s002230001134"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2004.09.059"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1089\/ten.2005.11.387"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.30236"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-007-3018-5"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-007-3143-1"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1002\/jor.22463"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.2217\/fmb.14.20"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1615\/jlongtermeffmedimplants.v21.i2.40"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1177\/145749691210100113"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.31263"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620x.96b6.33014"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1007\/s11845-012-0895-5"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199807)20:4&lt;315::AID-HED6>3.0.CO;2-1"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20436"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2004.00989.x"},{"issue":"6","key":"23","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1177\/000348941011900603","volume":"119","year":"2010","journal-title":"Annals of Otology, Rhinology and Laryngology"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1177\/0194599812438168"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1177\/000348941212100901"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-006-0103-4"},{"issue":"6","key":"27","first-page":"245","volume":"23","year":"2002","journal-title":"N\u00e9phrologie"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1080\/00016480310001042"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-013-2393-4"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1097\/mao.0000000000000702"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.3109\/00016487309139718"},{"issue":"1","key":"32","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0030-6665(20)33025-5","volume":"5","year":"1972","journal-title":"Otolaryngologic Clinics of North America"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2273.1994.tb01202.x"},{"issue":"8","key":"34","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1055\/s-2007-1008172","volume":"64","year":"1985","journal-title":"Laryngologie, Rhinologie, Otologie"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1159\/000276739"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.3342\/ceo.2012.5.1.23"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1016\/s0194-5998(99)70276-7"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e3181c9960d"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620x.83b1.11952"},{"issue":"3","key":"40","doi-asserted-by":"crossref","first-page":"454","DOI":"10.2106\/00004623-200203000-00020","volume":"84","year":"2002","journal-title":"The Journal of Bone & Joint Surgery\u2014American Volume"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1177\/000348949210100808"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1023\/a:1022828606312"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1177\/000348940411300907"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2015\/242319.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2015\/242319.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2015\/242319.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T01:23:54Z","timestamp":1599614634000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/bmri\/2015\/242319\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":43,"alternative-id":["242319","242319"],"URL":"https:\/\/doi.org\/10.1155\/2015\/242319","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}