{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T16:46:29Z","timestamp":1781196389491,"version":"3.54.1"},"reference-count":40,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,11,10]],"date-time":"2015-11-10T00:00:00Z","timestamp":1447113600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"University of Cape Coast"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Allergy"],"published-print":{"date-parts":[[2015,11,10]]},"abstract":"<jats:p><jats:italic>Heliotropium indicum<\/jats:italic> is used traditionally as a remedy for conjunctivitis in Ghana. This study therefore evaluated the antiallergic potential of an aqueous whole plant extract of <jats:italic>Heliotropium indicum<\/jats:italic> (HIE) in ovalbumin-induced allergic conjunctivitis and attempted to predict its mode of action. Clinical scores for allergic conjunctivitis induced by intraperitoneal ovalbumin sensitization (100\u2009:\u200910\u2009<jats:italic>\u03bc<\/jats:italic>g OVA\/Al(OH)<jats:sub>3<\/jats:sub> in phosphate-buffered saline [PBS]) and topical conjunctival challenge (1.5\u2009mg OVA in 10\u2009<jats:italic>\u03bc<\/jats:italic>L PBS) in Dunkin-Hartley guinea pigs were estimated after a week\u2019s daily treatment with 30\u2013300\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup> HIE, 30\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup> prednisolone, 10\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup> chlorpheniramine, or 10\u2009mL\u2009kg<jats:sup>\u22121<\/jats:sup> PBS. Ovalbumin-specific IgG and IgE and total IgE in serum were estimated using Enzyme-Linked Immunosorbent Assay. Histopathological assessment of the exenterated conjunctivae was also performed. The 30 and 300\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup> HIE treatment resulted in a significantly (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>\u2264<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>) low clinical score of allergic conjunctivitis. Ovalbumin-specific IgG and IgE as well as total serum IgE also decreased significantly (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>\u2264<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:math>\u20130.001). The conjunctival tissue in HIE treated guinea pigs had mild mononuclear infiltration compared to the PBS-treated ones, which had intense conjunctival tissue inflammatory infiltration. HIE exhibited antiallergic effect possibly by immunomodulation or immunosuppression.<\/jats:p>","DOI":"10.1155\/2015\/245370","type":"journal-article","created":{"date-parts":[[2015,11,10]],"date-time":"2015-11-10T21:01:03Z","timestamp":1447189263000},"page":"1-7","source":"Crossref","is-referenced-by-count":5,"title":["Possible Mechanism of Action of the Antiallergic Effect of an Aqueous Extract of <i>Heliotropium indicum<\/i> L. in Ovalbumin-Induced Allergic Conjunctivitis"],"prefix":"10.1155","volume":"2015","author":[{"given":"Samuel","family":"Kyei","sequence":"first","affiliation":[{"name":"Discipline of Optometry, School of Health Sciences, College of Health, University of KwaZulu-Natal, Durban 4041, South Africa"},{"name":"Department of Optometry, School of Allied Health Sciences, University of Cape Coast, Cape Coast, Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George Asumeng","family":"Koffuor","sequence":"additional","affiliation":[{"name":"Discipline of Optometry, School of Health Sciences, College of Health, University of KwaZulu-Natal, Durban 4041, South Africa"},{"name":"Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Ramkissoon","sequence":"additional","affiliation":[{"name":"Discipline of Optometry, School of Health Sciences, College of Health, University of KwaZulu-Natal, Durban 4041, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Abokyi","sequence":"additional","affiliation":[{"name":"Department of Optometry, School of Allied Health Sciences, University of Cape Coast, Cape Coast, 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