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This study was performed to evaluate the antifibrotic effect of date flesh extract (DFE) or date pits extract (DPE) via inactivation of hepatic stellate cells (HSCs), reducing the levels of inflammatory, fibrotic and angiogenic markers. Coffee was used as reference hepatoprotective agent. Liver fibrosis was induced by injection of CCl<jats:sub>4<\/jats:sub>(0.4\u2009mL\/kg) three times weekly for 8 weeks. DFE, DPE (6\u2009mL\/kg), coffee (300\u2009mg\/kg), and combination of coffee + DFE and coffee + DPE were given to CCl<jats:sub>4<\/jats:sub>-intoxicated rats daily for 8 weeks. DFE, DPE, and their combination with coffee attenuated the elevated levels of inflammatory cytokines including tumor necrosis factor-<jats:italic>\u03b1<\/jats:italic>, interleukin-6, and interleukin-1<jats:italic>\u03b2<\/jats:italic>. The increased levels of transforming growth factor-<jats:italic>\u03b2<\/jats:italic>1 and collagen deposition in injured liver were alleviated by both extracts. CCl<jats:sub>4<\/jats:sub>-induced expression of<jats:italic>\u03b1<\/jats:italic>-smooth muscle actin was suppressed indicating HSCs inactivation. Increased angiogenesis was ameliorated as revealed by reduced levels and expression of vascular endothelial growth factor and CD31. We concluded that DFE or DPE could protect liver via different mechanisms. The combination of coffee with DFE or DPE may enhance its antifibrotic effects.<\/jats:p>","DOI":"10.1155\/2015\/247357","type":"journal-article","created":{"date-parts":[[2015,4,8]],"date-time":"2015-04-08T15:07:29Z","timestamp":1428505649000},"page":"1-19","source":"Crossref","is-referenced-by-count":24,"title":["Aqueous Date Flesh or Pits Extract Attenuates Liver Fibrosis via Suppression of Hepatic Stellate Cell Activation and Reduction of Inflammatory Cytokines, Transforming Growth Factor-<b><i>\u03b2<\/i><\/b>1 and Angiogenic Markers in Carbon Tetrachloride-Intoxicated Rats"],"prefix":"10.1155","volume":"2015","author":[{"given":"Nouf M.","family":"Al-Rasheed","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11495, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hala A.","family":"Attia","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and 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