{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:31:51Z","timestamp":1792787511110,"version":"4.5.0"},"reference-count":53,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"JSPS KAKENHI","award":["23390040"],"award-info":[{"award-number":["23390040"]}]},{"name":"JSPS KAKENHI","award":["25870634"],"award-info":[{"award-number":["25870634"]}]},{"name":"JSPS KAKENHI","award":["23390040"],"award-info":[{"award-number":["23390040"]}]},{"name":"JSPS KAKENHI","award":["25870634"],"award-info":[{"award-number":["25870634"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neural Plasticity"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>\n                    Chondroitin sulfate proteoglycans (CSPGs) are major components of the extracellular matrix (ECM) in the brain. In adult mammals, CSPGs form the specialized ECM structure perineuronal nets (PNNs) that surround somata and dendrites of certain types of neurons. PNNs restrict synaptic plasticity and regulate the closure of critical periods. Although previous studies have examined the starting period of PNN formation, focusing on primary sensory cortices, there are no systematic studies at the whole brain level. Here, we examined the starting period of PNN formation in male mice ranging in age from postnatal day 3 to week 11, mainly focusing on several cortical areas, limbic structures, hypothalamus, and brain stem, using lectin histochemistry with\n                    <jats:italic>Wisteria floribunda<\/jats:italic>\n                    agglutinin (WFA). Results showed that early PNN formation was observed in several reticular formations of the brain stem related to the cranial nerves and primary somatosensory cortices. In the limbic system, PNN formation in the hippocampus started earlier than that of the amygdala. Furthermore, in the medial amygdaloid nucleus and some hypothalamic regions, WFA labeling did not show typical PNN-like forms. The present study suggests spatiotemporal differences at the beginning of PNN formation and a structural variety of CSPG-contained ECM in the brain.\n                  <\/jats:p>","DOI":"10.1155\/2015\/256389","type":"journal-article","created":{"date-parts":[[2015,11,16]],"date-time":"2015-11-16T16:00:57Z","timestamp":1447689657000},"page":"1-12","source":"Crossref","is-referenced-by-count":65,"title":["Development and Structural Variety of the Chondroitin Sulfate Proteoglycans-Contained Extracellular Matrix in the Mouse Brain"],"prefix":"10.1155","volume":"2015","author":[{"given":"Noriko","family":"Horii-Hayashi","sequence":"first","affiliation":[{"name":"Department of Anatomy and Cell Biology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8521, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayo","family":"Sasagawa","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, Nara Medical University, 840 Shijo-cho, 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