{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:04:24Z","timestamp":1785801864577,"version":"3.56.0"},"reference-count":40,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Natural Science Foundation Research Project of Shaanxi Province","award":["2014JM4146"],"award-info":[{"award-number":["2014JM4146"]}]},{"name":"Natural Science Foundation Research Project of Shaanxi Province","award":["2015.01\u20132017.12"],"award-info":[{"award-number":["2015.01\u20132017.12"]}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"crossref","award":["2014JM4146"],"award-info":[{"award-number":["2014JM4146"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"crossref","award":["2015.01\u20132017.12"],"award-info":[{"award-number":["2015.01\u20132017.12"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>In the preliminary study, we have found an excellent osteogenic property of nanohydroxyapatite\/chitosan\/poly(lactide-co-glycolide) (nHA\/CS\/PLGA) scaffolds seeded with human umbilical cord mesenchymal stem cells (hUCMSCs)<jats:italic>in vitro<\/jats:italic>and subcutaneously in the nude mice. The aim of this study was to further evaluate the osteogenic capacity of nHA\/CS\/PLGA scaffolds seeded with hUCMSCs in the calvarial defects of the nude mice. Totally 108 nude mice were included and divided into 6 groups: PLGA scaffolds + hUCMSCs; nHA\/PLGA scaffolds + hUCMSCs; CS\/PLGA scaffolds + hUCMSCs; nHA\/CS\/PLGA scaffolds + hUCMSCs; nHA\/CS\/PLGA scaffolds without seeding; the control group (no scaffolds) (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>18<\/mml:mn><\/mml:math>). The scaffolds were implanted into the calvarial defects of nude mice. The amount of new bones was evaluated by fluorescence labeling, H&amp;E staining, and Van Gieson staining at 4 and 8 weeks, respectively. The results demonstrated that the amount of new bones was significantly increased in the group of nHA\/CS\/PLGA scaffolds seeded with hUCMSCs (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:math>). On the basis of previous studies<jats:italic>in vitro<\/jats:italic>and in subcutaneous implantation of the nude mice, the results revealed that the nHA and CS also enhanced the bone regeneration by nHA\/CS\/PLGA scaffolds seeded with hUCMSCs in the calvarial defects of the nude mice at early stage.<\/jats:p>","DOI":"10.1155\/2015\/261938","type":"journal-article","created":{"date-parts":[[2015,10,14]],"date-time":"2015-10-14T01:02:07Z","timestamp":1444784527000},"page":"1-9","source":"Crossref","is-referenced-by-count":7,"title":["Bone Regeneration by Nanohydroxyapatite\/Chitosan\/Poly(lactide-co-glycolide) Scaffolds Seeded with Human Umbilical Cord Mesenchymal Stem Cells in the Calvarial Defects of the Nude Mice"],"prefix":"10.1155","volume":"2015","author":[{"given":"Fei","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Orthodontics, Stomatological Hospital, College of Medicine, Xi\u2019an Jiaotong University, Xi\u2019an 710004, 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