{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T08:36:01Z","timestamp":1790843761117,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2015]]},"abstract":"\n The worldwide increase of multidrug resistance in both community- and health-care associated bacterial infections has impaired the current antimicrobial therapy, warranting the search for other alternatives. We aimed to find the\n in vitro<\/jats:italic>\n antibacterial activity of ethanolic extracts of 16 different traditionally used medicinal plants of Nepal against 13 clinical and 2 reference bacterial species using microbroth dilution method. The evaluated plants species were found to exert a range of\n in vitro<\/jats:italic>\n growth inhibitory action against the tested bacterial species, and\n Cynodon dactylon<\/jats:italic>\n was found to exhibit moderate inhibitory action against 13 bacterial species including methicillin-resistant\n Staphylococcus aureus<\/jats:italic>\n , imipenem-resistant\n Pseudomonas aeruginosa<\/jats:italic>\n , multidrug-resistant\n Salmonella typhi<\/jats:italic>\n , and\n S. typhimurium<\/jats:italic>\n . The minimum inhibitory concentration (MIC) values of tested ethanolic extracts were found from 31 to >25,000\u2009\n \u03bc<\/jats:italic>\n g\/mL. Notably, ethanolic extracts of\n Cinnamomum camphora, Curculigo orchioides<\/jats:italic>\n , and\n Curcuma longa<\/jats:italic>\n exhibited the highest antibacterial activity against\n S. pyogenes<\/jats:italic>\n with a MIC of 49, 49, and 195\u2009\n \u03bc<\/jats:italic>\n g\/mL, respectively; whereas chloroform fraction of\n Cynodon dactylon<\/jats:italic>\n exhibited best antibacterial activity against\n S. aureus<\/jats:italic>\n with a MIC of 31\u2009\n \u03bc<\/jats:italic>\n g\/mL. Among all,\n C. dactylon, C. camphora, C. orchioides<\/jats:italic>\n , and\n C. longa<\/jats:italic>\n plant extracts displayed a potential antibacterial activity of MIC < 100\u2009\n \u03bc<\/jats:italic>\n g\/mL.\n <\/jats:p>","DOI":"10.1155\/2015\/265425","type":"journal-article","created":{"date-parts":[[2015,2,9]],"date-time":"2015-02-09T16:01:31Z","timestamp":1423497691000},"page":"1-6","source":"Crossref","is-referenced-by-count":81,"title":["Evaluation of Antibacterial Activity of Some Traditionally Used Medicinal Plants against Human Pathogenic Bacteria"],"prefix":"10.1155","volume":"2015","author":[{"given":"Bishnu P.","family":"Marasini","sequence":"first","affiliation":[{"name":"Central Department of Microbiology, Tribhuvan University, Kirtipur, Kathmandu, Nepal"},{"name":"Nepal Academy of Science and Technology (NAST), Khumaltar, Lalitpur, Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pankaj","family":"Baral","sequence":"additional","affiliation":[{"name":"Central Department of Microbiology, Tribhuvan University, Kirtipur, Kathmandu, Nepal"},{"name":"Department of Pathobiological Science, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pratibha","family":"Aryal","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kashi R.","family":"Ghimire","sequence":"additional","affiliation":[{"name":"Central Department of Microbiology, Tribhuvan University, Kirtipur, Kathmandu, Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjiv","family":"Neupane","sequence":"additional","affiliation":[{"name":"Central Department of Microbiology, Tribhuvan University, Kirtipur, Kathmandu, Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabaraj","family":"Dahal","sequence":"additional","affiliation":[{"name":"Patan Hospital, Patan, Lalitpur, Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjana","family":"Singh","sequence":"additional","affiliation":[{"name":"Central Department of Microbiology, Tribhuvan University, Kirtipur, Kathmandu, Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laxman","family":"Ghimire","sequence":"additional","affiliation":[{"name":"Department of Pathobiological Science, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanti","family":"Shrestha","sequence":"additional","affiliation":[{"name":"Nepal Academy of Science and Technology (NAST), Khumaltar, Lalitpur, Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1086\/595011"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2010.11.014"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2011.03570.x"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1086\/499819"},{"key":"5","year":"2002"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1186\/1746-4269-4-24"},{"key":"11","series-title":"CLSI Document M100-S17","year":"2007"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/0378-8741(94)90097-3"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/s0378-8741(97)00085-8"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2009.05.011"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.2165\/11317030-000000000-00000"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2010.07.048"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-10-64"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2005.01.062"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-12-74"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2012.05.005"},{"key":"22","first-page":"83","volume":"3","year":"2010","journal-title":"International Journal of Current Research"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1186\/1746-4269-8-19"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1007\/bf02862235"},{"key":"9","year":"2001"},{"key":"10","year":"2002"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2015\/265425.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2015\/265425.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2015\/265425.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,7,27]],"date-time":"2016-07-27T08:16:15Z","timestamp":1469607375000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/bmri\/2015\/265425\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":21,"alternative-id":["265425","265425"],"URL":"https:\/\/doi.org\/10.1155\/2015\/265425","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}