{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T22:19:25Z","timestamp":1785449965751,"version":"3.56.0"},"reference-count":34,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100004504","name":"Research Council of Lithuania","doi-asserted-by":"crossref","award":["MIP-011\/2014"],"award-info":[{"award-number":["MIP-011\/2014"]}],"id":[{"id":"10.13039\/501100004504","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004504","name":"Research Council of Lithuania","doi-asserted-by":"crossref","award":["La668\/11-2"],"award-info":[{"award-number":["La668\/11-2"]}],"id":[{"id":"10.13039\/501100004504","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004504","name":"Research Council of Lithuania","doi-asserted-by":"crossref","award":["La668\/15-1"],"award-info":[{"award-number":["La668\/15-1"]}],"id":[{"id":"10.13039\/501100004504","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004504","name":"Research Council of Lithuania","doi-asserted-by":"crossref","award":["Wi3278\/2-2"],"award-info":[{"award-number":["Wi3278\/2-2"]}],"id":[{"id":"10.13039\/501100004504","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"crossref","award":["MIP-011\/2014"],"award-info":[{"award-number":["MIP-011\/2014"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"crossref","award":["La668\/11-2"],"award-info":[{"award-number":["La668\/11-2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"crossref","award":["La668\/15-1"],"award-info":[{"award-number":["La668\/15-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"crossref","award":["Wi3278\/2-2"],"award-info":[{"award-number":["Wi3278\/2-2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"crossref","award":["MIP-011\/2014"],"award-info":[{"award-number":["MIP-011\/2014"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"crossref","award":["La668\/11-2"],"award-info":[{"award-number":["La668\/11-2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"crossref","award":["La668\/15-1"],"award-info":[{"award-number":["La668\/15-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"crossref","award":["Wi3278\/2-2"],"award-info":[{"award-number":["Wi3278\/2-2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"crossref","award":["MIP-011\/2014"],"award-info":[{"award-number":["MIP-011\/2014"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"crossref","award":["La668\/11-2"],"award-info":[{"award-number":["La668\/11-2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"crossref","award":["La668\/15-1"],"award-info":[{"award-number":["La668\/15-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"crossref","award":["Wi3278\/2-2"],"award-info":[{"award-number":["Wi3278\/2-2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>Progression of idiopathic dilated cardiomyopathy (IDCM) is marked with extensive left ventricular remodeling whose clinical manifestations and molecular basis are poorly understood. We aimed to evaluate the clinical potential of titin ligands in monitoring progression of cardiac remodeling associated with end-stage IDCM. Expression patterns of 8 mechanoptotic machinery-associated titin ligands (<jats:italic>ANKRD1<\/jats:italic>,<jats:italic>ANKRD2<\/jats:italic>,<jats:italic>TRIM63<\/jats:italic>,<jats:italic>TRIM55<\/jats:italic>,<jats:italic>NBR1<\/jats:italic>,<jats:italic>MLP<\/jats:italic>,<jats:italic>FHL2<\/jats:italic>, and<jats:italic>TCAP<\/jats:italic>) were quantitated in endomyocardial biopsies from 25 patients with advanced IDCM. When comparing NYHA disease stages, elevated<jats:italic>ANKRD1<\/jats:italic>expression levels marked transition from NYHA &lt; IV to NYHA IV.<jats:italic>ANKRD1<\/jats:italic>expression levels closely correlated with systolic strain depression and short E wave deceleration time, as determined by echocardiography. On molecular level, myocardial<jats:italic>ANKRD1<\/jats:italic>and serum adiponectin correlated with low<jats:italic>BAX\/BCL-2<\/jats:italic>ratios, indicative of antiapoptotic tissue propensity observed during the worsening of heart failure. ANKRD1 is a potential marker for cardiac remodeling and disease progression in IDCM.<jats:italic>ANKRD1<\/jats:italic>expression correlated with reduced cardiac contractility and compliance. The association of<jats:italic>ANKRD1<\/jats:italic>with antiapoptotic response suggests its role as myocyte survival factor during late stage heart disease, warranting further studies on ANKRD1 during end-stage heart failure.<\/jats:p>","DOI":"10.1155\/2015\/273936","type":"journal-article","created":{"date-parts":[[2015,4,16]],"date-time":"2015-04-16T20:08:42Z","timestamp":1429214922000},"page":"1-9","source":"Crossref","is-referenced-by-count":37,"title":["Induction of Ankrd1 in Dilated Cardiomyopathy Correlates with the Heart Failure Progression"],"prefix":"10.1155","volume":"2015","author":[{"given":"Julius","family":"Bogomolovas","sequence":"first","affiliation":[{"name":"Department of Integrative Pathophysiology, Medical Faculty Mannheim, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany"},{"name":"Department of Pathology, Forensic Medicine and Pharmacology, Faculty of Medicine, Vilnius University, M. K. Ciurlionio g. 21, LT-03101 Vilnius, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin","family":"Brohm","sequence":"additional","affiliation":[{"name":"Department of Integrative Pathophysiology, Medical Faculty Mannheim, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelena","family":"\u010celutkien\u0117","sequence":"additional","affiliation":[{"name":"Vilnius University Hospital Santariskiu Klinikos, Santari\u0161kiu g. 2, LT-08661 Vilnius, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giedr\u0117","family":"Bal\u010di\u016bnait\u0117","sequence":"additional","affiliation":[{"name":"Vilnius University Hospital Santariskiu Klinikos, Santari\u0161kiu g. 2, LT-08661 Vilnius, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiva","family":"Bironait\u0117","sequence":"additional","affiliation":[{"name":"State Research Institute, Center for Innovative Medicine, Department of Stem Cell Biology, \u017dygimantu g. 9, LT-01102 Vilnius, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginija","family":"Bukelskien\u0117","sequence":"additional","affiliation":[{"name":"Vilnius University Institute of Biochemistry, Mokslininku g. 12, LT-08660 Vilnius, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dainius","family":"Daunoravi\u010dus","sequence":"additional","affiliation":[{"name":"Department of Pathology, Forensic Medicine and Pharmacology, Faculty of Medicine, Vilnius University, M. K. Ciurlionio g. 21, LT-03101 Vilnius, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian C.","family":"Witt","sequence":"additional","affiliation":[{"name":"Department of Integrative Pathophysiology, Medical Faculty Mannheim, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Fielitz","sequence":"additional","affiliation":[{"name":"Experimental and Clinical Research Center (ECRC), Max-Delbrueck Center for Molecular Medicine (MDC), Robert-R\u00f6ssle-Stra\u00dfe 10, Buch, 13125 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginija","family":"Grabauskien\u0117","sequence":"additional","affiliation":[{"name":"Department of Pathology, Forensic Medicine and Pharmacology, Faculty of Medicine, Vilnius University, M. K. Ciurlionio g. 21, LT-03101 Vilnius, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siegfried","family":"Labeit","sequence":"additional","affiliation":[{"name":"Department of Integrative Pathophysiology, Medical Faculty Mannheim, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2008.10.083"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.86.11.1107"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1007\/s12013-012-9430-6"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2003.09.012"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.36.1.48"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000135591.37759.AF"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfp049"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.02.076"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.12.082"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.3858\/emm.2009.41.4.027"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M501095200"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvu001"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.5.572"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035743"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-7-85"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1161\/hc0102.101396"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.7.1933"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200317664"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1089\/10430340152677403"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.112.000627"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90509-O"},{"issue":"1","key":"22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj3260001","volume":"326","year":"1997","journal-title":"The Biochemical Journal"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5273(01)00451-X"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2008.10.006"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.90.6.2772"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejheart.2006.06.002"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)00647-1"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.530972"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00445.2013"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.89.1.151"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118280"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1110186"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.02.076"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp225"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2015\/273936.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2015\/273936.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2015\/273936.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T05:36:35Z","timestamp":1498196195000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/bmri\/2015\/273936\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":34,"alternative-id":["273936","273936"],"URL":"https:\/\/doi.org\/10.1155\/2015\/273936","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}