{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T18:37:25Z","timestamp":1773772645063,"version":"3.50.1"},"reference-count":53,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["308311\/2009-4"],"award-info":[{"award-number":["308311\/2009-4"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["301779\/2009-0"],"award-info":[{"award-number":["301779\/2009-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["308311\/2009-4"],"award-info":[{"award-number":["308311\/2009-4"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["301779\/2009-0"],"award-info":[{"award-number":["301779\/2009-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>The objective of this study was to estimate the protective effect of Bacille Calmette-Gu\u00e9rin (BCG) vaccine against tuberculosis among (predominantly immunodeficient) HIV-infected children in Angola. A hospital-based case-control study was conducted with 230 cases, children coinfected with tuberculosis, and 672 controls, HIV-infected children from the same hospital, aged 18 months to 13 years. The presence of a vaccination scar was taken as a proxy marker for BCG vaccination. The crude effectiveness was 8% (95% CI: \u221226 to 32) and the adjusted effectiveness was 30% (95% CI: \u221275 to 72). The present study suggests that BCG does not have a protective effect against tuberculosis among immunodeficient HIV-infected children. Since BCG is no longer given to HIV-infected children, the study may not be replicated. Accepting that these findings should be considered with caution, they are nonetheless likely to be the last estimate of BCG efficacy in a sufficiently powered study.<\/jats:p>","DOI":"10.1155\/2015\/275029","type":"journal-article","created":{"date-parts":[[2015,6,29]],"date-time":"2015-06-29T22:55:42Z","timestamp":1435618542000},"page":"1-10","source":"Crossref","is-referenced-by-count":10,"title":["Effectiveness of the First Dose of BCG against Tuberculosis among HIV-Infected, Predominantly Immunodeficient Children"],"prefix":"10.1155","volume":"2015","author":[{"given":"Joaquim C. V. D.","family":"Van-Dunem","sequence":"first","affiliation":[{"name":"Departamento de Pediatria, Universidade Agostinho Neto, Avenida Amilcar Cabral, s\/n, Maianga, Luanda, Angola"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura C.","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz Claudio Arraes","family":"Alencar","sequence":"additional","affiliation":[{"name":"Departamento de Medicina Tropical, Universidade Federal de Pernambuco, Avenida Professor Moraes R\u00eago, s\/n, Bloco A do Hospital das Cl\u00ednicas, Cidade Universit\u00e1ria, 50670-420 Recife, PE, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria de F\u00e1tima Pessoa","family":"Milit\u00e3o-Albuquerque","sequence":"additional","affiliation":[{"name":"P\u00f3s-Gradua\u00e7\u00e3o em Medicina Tropical, Universidade Federal de Pernambuco, Avenida Professor Moraes R\u00eago, s\/n, Bloco A do Hospital das Cl\u00ednicas, Cidade Universit\u00e1ria, 50670-420 Recife, PE, Brazil"},{"name":"Departamento de Sa\u00fade Coletiva, CPqAM, FIOCRUZ, Avenida Professor Moraes R\u00eago, s\/n, Campus da UFPE, Cidade Universit\u00e1ria, 50670-420 Recife, PE, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo Arraes de Alencar","family":"Ximenes","sequence":"additional","affiliation":[{"name":"Departamento de Medicina Tropical, Universidade Federal de Pernambuco, Avenida Professor Moraes R\u00eago, s\/n, Bloco A do Hospital das Cl\u00ednicas, Cidade Universit\u00e1ria, 50670-420 Recife, PE, Brazil"},{"name":"Programa de Mestrado e Doutorado em Ci\u00eancias da Sa\u00fade, UPE, Rua Arn\u00f3bio Marques, No. 310, Santo Amaro, 50100-130 Recife, PE, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","year":"2013"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/20.1.11"},{"issue":"1","key":"5","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1542\/peds.96.1.29","volume":"96","year":"1995","journal-title":"Pediatrics"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/22.6.1154"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/s1473-3099(02)00182-2"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5419.1520"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1086\/653533"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit790"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199312000-00006"},{"issue":"3","key":"12","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1542\/peds.95.3.414","volume":"95","year":"1995","journal-title":"Pediatrics"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199609000-00023"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1086\/378298"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1086\/499953"},{"key":"16","first-page":"27","volume":"79","year":"2004","journal-title":"The Weekly Epidemiological Record"},{"key":"17","first-page":"181","volume":"82","year":"2007","journal-title":"Weekly Epidemiological Record"},{"issue":"1","key":"18","first-page":"61","volume":"81","year":"2003","journal-title":"Bulletin of the World Health Organization"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/712736"},{"key":"24","year":"2004"},{"key":"20","year":"1983"},{"key":"21","first-page":"87","volume":"142","year":"2004","journal-title":"Acta M\u00e9dica Angolana"},{"issue":"3","key":"22","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1093\/oxfordjournals.bmb.a072277","volume":"44","year":"1988","journal-title":"British Medical Bulletin"},{"issue":"3","key":"25","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1093\/oxfordjournals.bmb.a072276","volume":"44","year":"1988","journal-title":"British Medical Bulletin"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/39.4.219"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/29.6.1085"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/146.6.1439"},{"key":"32","first-page":"S1","volume":"72","year":"1980","journal-title":"Indian Journal of Medical Research"},{"issue":"2","key":"33","first-page":"171","volume":"93","year":"1966","journal-title":"American Review of Respiratory Disease"},{"issue":"8369","key":"34","first-page":"145","volume":"1","year":"1984","journal-title":"The Lancet"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.6082.293"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.3310\/hta17370"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1086\/314073"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(95)92348-9"},{"issue":"4","key":"39","first-page":"553","volume":"94","year":"1966","journal-title":"The American Review of Respiratory Disease"},{"issue":"9","key":"40","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1001\/jama.1994.03510330076038","volume":"271","year":"1994","journal-title":"The Journal of the American Medical Association"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/20.4.982"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-3879(82)80006-8"},{"issue":"1","key":"43","first-page":"35","volume":"67","year":"1989","journal-title":"Bulletin of the World Health Organization"},{"issue":"2","key":"44","first-page":"75","volume":"35","year":"1990","journal-title":"The Ceylon Mmedical Journal"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1136\/adc.67.1.80"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2214.1993.tb00711.x"},{"issue":"3","key":"47","first-page":"141","volume":"20","year":"1977","journal-title":"Papua and New Guinea Medical Journal"},{"issue":"3-4","key":"48","first-page":"101","volume":"55","year":"1980","journal-title":"Bulletin of the International Union against Tuberculosis"},{"key":"49","first-page":"S1","volume":"72","year":"1980","journal-title":"Indian Journal of Medical Research"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2009.12.034"},{"issue":"11","key":"50","first-page":"1067","volume":"5","year":"2001","journal-title":"International Journal of Tuberculosis and Lung Disease"},{"issue":"12","key":"51","first-page":"1133","volume":"4","year":"2000","journal-title":"International Journal of Tuberculosis and Lung Disease"},{"issue":"4","key":"52","first-page":"425","volume":"69","year":"1991","journal-title":"Bulletin of the World Health Organization"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/14.3.441"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.1128\/iai.70.2.672-678.2002"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1038\/nri1666"},{"issue":"1","key":"57","first-page":"57","volume":"66","year":"1991","journal-title":"Bulletin of the International Union Against Tuberculosis and Lung Disease"},{"issue":"9","key":"58","first-page":"806","volume":"6","year":"2002","journal-title":"The International Journal of Tuberculosis and Lung Disease"},{"key":"59","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3156.2002.00882.x"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2015\/275029.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2015\/275029.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2015\/275029.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T00:17:06Z","timestamp":1652660226000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/bmri\/2015\/275029\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":53,"alternative-id":["275029","275029"],"URL":"https:\/\/doi.org\/10.1155\/2015\/275029","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}