{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:24:27Z","timestamp":1789950267544,"version":"4.0.1"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,11,5]],"date-time":"2015-11-05T00:00:00Z","timestamp":1446681600000},"content-version":"vor","delay-in-days":308,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Ministry of Health & Welfare, Republic of Korea","award":["HI14C1842"],"award-info":[{"award-number":["HI14C1842"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:p>In the trigeminal system, disruption of acute resolution processing may lead to uncontrolled inflammation and chronic pain associated with the temporomandibular joint (TMJ). Currently, there are no effective treatments for TMJ pain. Recently, it has been recognized that maresin 1, a newly identified macrophage\u2010derived mediator of inflammation resolution, is a potent analgesic for somatic inflammatory pain without noticeable side effects in mice and a potent endogenous inhibitor of transient receptor potential vanilloid 1 (TRPV1) in the somatic system. However, the molecular mechanisms underlying the analgesic actions of maresin 1 on TMJ pain are unclear in the trigeminal system. Here, by performing TMJ injection of a retrograde labeling tracer DiI (a fluorescent dye), I showed that maresin 1 potently inhibits capsaicin\u2010induced TRPV1 currents and neuronal activity via G<jats:italic>\u03b1<\/jats:italic>i\u2010coupled G\u2010protein coupled receptors in DiI\u2010labeled trigeminal nociceptive neurons. Further, maresin 1 blocked TRPV1 agonist\u2010evoked increases in spontaneous excitatory postsynaptic current frequency and abolished TMJ inflammation\u2010induced synaptic plasticity in the trigeminal nucleus. These results demonstrate the potent actions of maresin 1 in regulating TRPV1 in the trigeminal system. Thus, maresin 1 may serve as a novel endogenous inhibitor for treating TMJ\u2010inflammatory pain in the orofacial region.<\/jats:p>","DOI":"10.1155\/2015\/275126","type":"journal-article","created":{"date-parts":[[2015,11,5]],"date-time":"2015-11-05T21:01:30Z","timestamp":1446757290000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Maresin 1 Inhibits TRPV1 in Temporomandibular Joint\u2010Related Trigeminal Nociceptive Neurons and TMJ Inflammation\u2010Induced Synaptic Plasticity in the Trigeminal Nucleus"],"prefix":"10.1155","volume":"2015","author":[{"given":"Chul-Kyu","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,5]]},"reference":[{"key":"e_1_2_7_1_2","first-page":"1477","article-title":"Temporomandibular joint disorders","volume":"76","author":"Buescher J. 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