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Thirty diabetic hind limb ischemic model mice and ten normal mice, established by intraperitoneal (i.p.) injection of streptozotocin (STZ) or PBS and ligation\/excision of femoral artery, and then twenty diabetic hind limb ischemic model mice of all were evenly randomized to saline (control,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>10<\/mml:mn><\/mml:math>) and DH i.p. injection (2\u2009mL\/kg weight for 7 days,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>10<\/mml:mn><\/mml:math>) groups. Limb perfusion recovery and femoral blood hydrogen sulfide (H<jats:sub>2<\/jats:sub>S) and vessel regeneration and lower limb vascular endothelial growth factor (VEGF)\/cystathionine<jats:italic>\u03b3<\/jats:italic>-lyase (CSE) expression were evaluated during intervention and after euthanasia, respectively. DH i.p. increased ischemic limb perfusion and promoted collateral circulation generation without decreasing blood glucose level. Increased local CSE-H<jats:sub>2<\/jats:sub>S-VEGF expression contributed to beneficial effects of DH injection. In conclusion, activation of local CSE-H<jats:sub>2<\/jats:sub>S-VEGF axis might participate in proangiogenesis effects of DH injection in diabetic hind limb ischemia model mice, suggesting a potential therapy for diabetic patients with critical limb ischemia.<\/jats:p>","DOI":"10.1155\/2015\/276263","type":"journal-article","created":{"date-parts":[[2015,9,30]],"date-time":"2015-09-30T17:21:21Z","timestamp":1443633681000},"page":"1-8","source":"Crossref","is-referenced-by-count":8,"title":["Danhong Promotes Angiogenesis in Diabetic Mice after Critical Limb Ischemia by Activation of CSE-H<sub>2<\/sub>S-VEGF Axis"],"prefix":"10.1155","volume":"2015","author":[{"given":"Feng","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Cardiology, Shanghai Changzheng Hospital, Second Military Medical University, No. 415, Fengyang Road, Huangpu District, Shanghai 200003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiqing","family":"He","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai Changzheng Hospital, Second Military Medical University, No. 415, Fengyang Road, Huangpu District, Shanghai 200003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ru","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai Changzheng Hospital, Second Military Medical University, No. 415, Fengyang Road, Huangpu District, Shanghai 200003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhigang","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai Changzheng Hospital, Second Military Medical University, No. 415, Fengyang Road, Huangpu District, Shanghai 200003, 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