{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:15:50Z","timestamp":1791353750776,"version":"4.3.1"},"reference-count":45,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Rheumatoid arthritis is a systemic autoimmune disease characterized by joint erosions, progressive focal bone loss, and chronic inflammation.<jats:italic>Methods<\/jats:italic>. 20 female patients with moderate-to-severe rheumatoid arthritis were treated with anti-TNF-antibody adalimumab in addition to concomitant antirheumatic therapies. Patients were assessed for overall disease activity using the DAS28 score, and neopterin, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) concentrations as well as osteoprotegerin (OPG) and soluble receptor activator of NF-<jats:italic>\u03ba<\/jats:italic>B ligand (sRANKL) concentrations were determined before therapy and at week 12. Neopterin as well as OPG and sRANKL were determined by commercial ELISAs.<jats:italic>Results<\/jats:italic>. Before anti-TNF therapy patients presented with high disease activity and elevated concentrations of circulating inflammatory markers. OPG concentrations correlated with neopterin (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>r<\/mml:mi><mml:mi>s<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.494<\/mml:mn><\/mml:math>,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0<\/mml:mn><mml:mo>.<\/mml:mo><mml:mn>027<\/mml:mn><\/mml:math>), but not with DAS28. OPG concentrations and disease activity scores declined during anti-TNF-treatment (both<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0<\/mml:mn><mml:mo>.<\/mml:mo><mml:mn>02<\/mml:mn><\/mml:math>). Patients who achieved remission (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>7<\/mml:mn><\/mml:math>) or showed a good response according to EULAR criteria (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>13<\/mml:mn><\/mml:math>) presented with initially higher baseline OPG levels, which subsequently decreased significantly during treatment (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0<\/mml:mn><mml:mo>.<\/mml:mo><mml:mn>018<\/mml:mn><\/mml:math>for remission,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0<\/mml:mn><mml:mo>.<\/mml:mo><mml:mn>011<\/mml:mn><\/mml:math>for good response).<jats:italic>Conclusions<\/jats:italic>. Adalimumab therapy was effective in modifying disease activity and reducing proinflammatory and bone remodelling cascades.<\/jats:p>","DOI":"10.1155\/2015\/276969","type":"journal-article","created":{"date-parts":[[2015,10,21]],"date-time":"2015-10-21T21:04:07Z","timestamp":1445461447000},"page":"1-7","source":"Crossref","is-referenced-by-count":10,"title":["Effects of Antitumor Necrosis Factor Therapy on Osteoprotegerin, Neopterin, and sRANKL Concentrations in Patients with Rheumatoid Arthritis"],"prefix":"10.1155","volume":"2015","author":[{"given":"Katharina","family":"Kurz","sequence":"first","affiliation":[{"name":"Department of Internal Medicine VI, Innsbruck Medical University, 6020 Innsbruck, Austria"},{"name":"Division of Biological Chemistry, Biocenter, Innsbruck Medical University, 6020 Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manfred","family":"Herold","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 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