{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T04:31:36Z","timestamp":1784867496515,"version":"3.55.0"},"reference-count":24,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sleep Disorders"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p><jats:italic>Objectives<\/jats:italic>. To study the relationship between nocturnal periodic breathing episodes and behavioral awakenings at high altitude.<jats:italic>Methods<\/jats:italic>. Observational study. It is 6-day ascent of 4 healthy subjects from Besisahar (760 meters) to Manang (3540 meters) in Nepal in March 2012. A recording pulse oximeter was worn by each subject to measure their oxygen saturation and the presence of periodic breathing continuously through the night. An actigraph was simultaneously worn in order to determine nocturnal behavioral awakenings. There were no interventions.<jats:italic>Results<\/jats:italic>. 187-hour sleep at high altitude was analyzed, and of this, 145 hours (78%) had at least one PB event. At high altitude, 10.5% (95% CI 6.5\u201314.6%) of total sleep time was spent in PB while 15 out of 50 awakenings (30%, 95% CI: 18\u201345%) occurring at high altitudes were associated with PB (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>).<jats:italic>Conclusions<\/jats:italic>. Our data reveals a higher than expected number of behavioral awakenings associated with PB compared to what would be expected by chance. This suggests that PB likely plays a role in behavioral awakenings at high altitude.<\/jats:p>","DOI":"10.1155\/2015\/279263","type":"journal-article","created":{"date-parts":[[2015,9,21]],"date-time":"2015-09-21T21:01:55Z","timestamp":1442869315000},"page":"1-6","source":"Crossref","is-referenced-by-count":6,"title":["Periodic Breathing and Behavioral Awakenings at High Altitude"],"prefix":"10.1155","volume":"2015","author":[{"given":"Daniel J.","family":"Shogilev","sequence":"first","affiliation":[{"name":"Division of Emergency Medicine, Duke University, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John B.","family":"Tanner","sequence":"additional","affiliation":[{"name":"Division of Wilderness Medicine, Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchiao","family":"Chang","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine, Massachusetts General Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. Stuart","family":"Harris","sequence":"additional","affiliation":[{"name":"Division of Wilderness Medicine, Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"98","reference":[{"issue":"4","key":"1","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1001\/archinte.1970.00310040073007","volume":"125","year":"1970","journal-title":"Archives of Internal Medicine"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-999-0089-1"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2869.2009.00745.x"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200911-1694oc"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1089\/1527029041352162"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1983.sp014906"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.1708"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(75)90188-1"},{"issue":"5","key":"9","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1093\/sleep\/15.5.461","volume":"15","year":"1992","journal-title":"Sleep"},{"issue":"1","key":"10","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1093\/sleep\/26.1.81","volume":"26","year":"2003","journal-title":"Sleep"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2010.10.001"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2869.2006.00558.x"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1089\/ham.2010.1073"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1089\/ham.2008.1039"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1053\/smrv.2001.0202"},{"key":"16","first-page":"273","volume-title":"The Lake Louise acute mountain sickness scoring system","year":"1993"},{"issue":"8","key":"17","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1093\/sleep\/24.8.957","volume":"24","year":"2001","journal-title":"Sleep"},{"issue":"1","key":"18","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1093\/sleep\/27.1.158","volume":"27","year":"2004","journal-title":"Sleep"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/s0165-0270(00)00364-2"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/s0031-9384(00)00355-3"},{"issue":"10","key":"21","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1093\/sleep\/29.10.1353","volume":"29","year":"2006","journal-title":"Sleep"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.98.12020408"},{"issue":"3","key":"23","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1152\/jappl.1992.72.3.985","volume":"72","year":"1992","journal-title":"Journal of Applied Physiology"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(95)00057-7"}],"container-title":["Sleep Disorders"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/sd\/2015\/279263.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/sd\/2015\/279263.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/sd\/2015\/279263.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T20:47:52Z","timestamp":1567198072000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/sd\/2015\/279263\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":24,"alternative-id":["279263","279263"],"URL":"https:\/\/doi.org\/10.1155\/2015\/279263","relation":{},"ISSN":["2090-3545","2090-3553"],"issn-type":[{"value":"2090-3545","type":"print"},{"value":"2090-3553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}