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Male BALB\/c mice underwent unilateral ureteral ligation (UUO) or sham operation and received exogenously administered Ac\u2010SDKP delivered via a subcutaneous osmotic minipump or Captopril treatment by oral gavage. Seven days after UUO, there were significant reductions in the expression of both collagen 1 and collagen 3 in kidneys treated with Ac\u2010SDKP or Captopril, and there was a trend towards reductions in collagen IV, <jats:italic>\u03b1<\/jats:italic>\u2010SMA, and MCP\u20101 versus control. However, no significant attenuation of interstitial injury or macrophage infiltration was observed. These findings are in contrary to observations in other models and underscore the fact that a longer treatment time frame may be required to yield anti\u2010inflammatory effects in BALB\/c mice treated with Ac\u2010SDKP compared to untreated mice. 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