{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T08:57:33Z","timestamp":1758272253247},"reference-count":16,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Infectious Diseases"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>Tuberculosis is an opportunistic infection with protean clinical manifestations. We describe a case of Ruxolitinib induced miliary tuberculosis presenting as a neck lump. A 78-year-old female presented with a two-month history of right-sided neck lump associated with fever, night sweats, and significant weight loss. She had a past medical history that included myelofibrosis, being treated with Ruxolitinib. Examination demonstrated 4 \u00d7 4\u2009cm right-sided cervical lymphadenopathy. A chest radiograph showed extensive shadowing in both lungs. CT scan demonstrated perilymphatic nodes in addition to the cervical mass. An ultrasound-guided biopsy of a cervical lymph node demonstrated confirmed<jats:italic>Mycobacterium tuberculosis<\/jats:italic>infection. It was hypothesized that use of Ruxolitinib through its selective inhibition of Janus-activated kinases 1 and 2 resulted in immunosuppression and miliary tuberculosis in this patient. The medication was stopped and a 12-month regime of antituberculosis therapy commenced. She remained well at one-year follow-up with resolution of lung involvement. Clinicians should consider tuberculosis as a differential diagnosis for patients presenting with a neck lump, particularly in those taking immunosuppressant medication such as Ruxolitinib. A multidisciplinary approach is needed to promptly treat the tuberculosis and consider discontinuation of Ruxolitinib.<\/jats:p>","DOI":"10.1155\/2015\/284168","type":"journal-article","created":{"date-parts":[[2015,12,15]],"date-time":"2015-12-15T23:37:18Z","timestamp":1450222638000},"page":"1-3","source":"Crossref","is-referenced-by-count":10,"title":["Ruxolitinib Associated Tuberculosis Presenting as a Neck Lump"],"prefix":"10.1155","volume":"2015","author":[{"given":"Eamon","family":"Shamil","sequence":"first","affiliation":[{"name":"ENT Department, Addenbrooke\u2019s Hospital, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge CB2 0QQ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Cunningham","sequence":"additional","affiliation":[{"name":"ENT Department, Addenbrooke\u2019s Hospital, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge CB2 0QQ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Billy L. K.","family":"Wong","sequence":"additional","affiliation":[{"name":"ENT Department, Addenbrooke\u2019s Hospital, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge CB2 0QQ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piyush","family":"Jani","sequence":"additional","affiliation":[{"name":"ENT Department, Addenbrooke\u2019s Hospital, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge CB2 0QQ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-5-2101791285670497"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)71142-9"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-02-485888"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa051113"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.22210"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1110557"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1002028"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1110556"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1056\/nejmc1302895"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-1604"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.118935"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1002\/art.21137"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.104"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-014-2183-0"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2014.963082"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-10-531103"}],"container-title":["Case Reports in Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/criid\/2015\/284168.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/criid\/2015\/284168.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/criid\/2015\/284168.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,8,18]],"date-time":"2016-08-18T17:06:46Z","timestamp":1471540006000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/criid\/2015\/284168\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":16,"alternative-id":["284168","284168"],"URL":"https:\/\/doi.org\/10.1155\/2015\/284168","relation":{},"ISSN":["2090-6625","2090-6633"],"issn-type":[{"value":"2090-6625","type":"print"},{"value":"2090-6633","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}