{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T17:42:27Z","timestamp":1764783747527},"reference-count":45,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Walloon Region (Belgium)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computational and Mathematical Methods in Medicine"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>Radioimmunotherapy has shown that the use of monoclonal antibodies combined with a radioisotope like<jats:sup>131<\/jats:sup>I or<jats:sup>90<\/jats:sup>Y still remains ineffective for solid and radioresistant tumour treatment. Previous simulations have revealed that an increase in the number of<jats:sup>90<\/jats:sup>Y labelled to each antibody or nanoobject could be a solution to improve treatment output. It now seems important to assess the treatment output and toxicity when radionuclides such as<jats:sup>90<\/jats:sup>Y,<jats:sup>177<\/jats:sup>Lu,<jats:sup>131<\/jats:sup>I,<jats:sup>124<\/jats:sup>I, and<jats:sup>188<\/jats:sup>Re are used. Tumour control probability (TCP) and normal tissue complication probability (NTCP) curves versus the number of radionuclides per nanoobject were computed with MCNPX to evaluate treatment efficacy for solid tumours and to predict the incidence of surrounding side effects. Analyses were carried out for two solid tumour sizes of 0.5 and 1.0\u2009cm radius and for nanoobject (i.e., a radiolabelled antibody) distributed uniformly or nonuniformly throughout a solid tumour (e.g., Non-small-cell-lung cancer (NSCLC)).<jats:sup>90<\/jats:sup>Y and<jats:sup>188<\/jats:sup>Re are the best candidates for solid tumour treatment when only one radionuclide is coupled to one carrier. Furthermore, regardless of the radionuclide properties, high values of TCP can be reached without toxicity if the number of radionuclides per nanoobject increases.<\/jats:p>","DOI":"10.1155\/2015\/284360","type":"journal-article","created":{"date-parts":[[2015,6,3]],"date-time":"2015-06-03T20:54:10Z","timestamp":1433364850000},"page":"1-15","source":"Crossref","is-referenced-by-count":11,"title":["Monte Carlo Calculation of Radioimmunotherapy with<sup>90<\/sup>Y-,<sup>177<\/sup>Lu-,<sup>131<\/sup>I-,<sup>124<\/sup>I-, and<sup>188<\/sup>Re-Nanoobjects: Choice of the Best Radionuclide for Solid Tumour Treatment by Using TCP and NTCP Concepts"],"prefix":"10.1155","volume":"2015","author":[{"given":"S.","family":"Lucas","sequence":"first","affiliation":[{"name":"Research Centre for the Physics of Matter and Radiation (PMR), University of Namur, 61 Rue de Bruxelles, 5000 Namur, Belgium"},{"name":"NAmur Research Institute for LIfe Sciences (NARILIS), University of Namur, 61 Rue de Bruxelles, 5000 Namur, Belgium"}]},{"given":"O.","family":"Feron","sequence":"additional","affiliation":[{"name":"Pharmacology and Therapeutics Unit (FATH), Institute of Experimental and Clinical Research (IREC), Universit\u00e9 Catholique de Louvain (UCL), 53 Avenue Mounier, 1200 Brussels, Belgium"}]},{"given":"B.","family":"Gallez","sequence":"additional","affiliation":[{"name":"Biomedical Magnetic Resonance Group (REMA), Louvain Drug Research Institute, Universit\u00e9 Catholique de Louvain (UCL), 73 Avenue Mounier, 1200 Brussels, Belgium"}]},{"given":"B.","family":"Masereel","sequence":"additional","affiliation":[{"name":"NAmur Research Institute for LIfe Sciences (NARILIS), University of Namur, 61 Rue de Bruxelles, 5000 Namur, Belgium"},{"name":"Namur Medicine and Drug Innovation Center (NAMEDIC), University of Namur, 61 Rue de Bruxelles, 5000 Namur, Belgium"}]},{"given":"C.","family":"Michiels","sequence":"additional","affiliation":[{"name":"NAmur Research Institute for LIfe Sciences (NARILIS), University of Namur, 61 Rue de Bruxelles, 5000 Namur, Belgium"},{"name":"Unit\u00e9 de Recherche en Biologie Cellulaire (URBC), University of Namur, 61 Rue de Bruxelles, 5000 Namur, Belgium"}]},{"given":"T.","family":"Vander Borght","sequence":"additional","affiliation":[{"name":"NAmur Research Institute for LIfe Sciences (NARILIS), University of Namur, 61 Rue de Bruxelles, 5000 Namur, Belgium"},{"name":"Centre for Molecular Imaging, Radiotherapy and Oncology (MIRO), Institute of Experimental and Clinical Research (IREC), Universit\u00e9 Catholique de Louvain (UCL), 1 Dr. G. 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