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Treatment response at 24\u2009wk was used as the primary outcome, measured by a composite of improvement in Clinical Activity Score (CAS), diplopia, motility, soft tissue swelling, proptosis, and eyelid aperture. Secondary outcome was the change of quality of life score (QoL, including visual functioning subscale and appearance subscale). Adverse events were also recorded.<jats:italic>Results.<\/jats:italic>Overall improvement was noted in eight out of 13 patients (61.5%, 95% CI 31.6%\u201386.1%). Both CAS and soft tissue swelling significantly ameliorated in eight patients at 24\u2009wk. Five patients (38.5%) had improvement in ocular motility of \u22658 degrees. Eyelid aperture (46.2%) also decreased remarkably. For QoL, a significant improvement in appearance subscale (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.008<\/mml:mn><\/mml:math>) was noted during the study, whereas no difference was observed in visual functioning subscale (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.21<\/mml:mn><\/mml:math>). Two patients reported mild stomachache at 12\u2009wk.<jats:italic>Conclusions.<\/jats:italic>SD doxycycline appears to be effective and safe for the treatment of active and moderate-to-severe GO. It might serve as a new promising therapeutic strategy for GO. This trial is registered with<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT01727973?term=NCT01727973&amp;rank=1\">NCT01727973<\/jats:ext-link>.<\/jats:p>","DOI":"10.1155\/2015\/285698","type":"journal-article","created":{"date-parts":[[2015,6,29]],"date-time":"2015-06-29T17:02:57Z","timestamp":1435597377000},"page":"1-8","source":"Crossref","is-referenced-by-count":7,"title":["Efficacy of Subantimicrobial Dose Doxycycline for Moderate-to-Severe and Active Graves\u2019 Orbitopathy"],"prefix":"10.1155","volume":"2015","author":[{"given":"Miaoli","family":"Lin","sequence":"first","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, No. 54 Xianlie Road, Guangzhou 510060, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxiang","family":"Mao","sequence":"additional","affiliation":[{"name":"State Key Laboratory 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