{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:18:07Z","timestamp":1790518687835,"version":"4.1.0"},"reference-count":80,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["209981\/2013-0"],"award-info":[{"award-number":["209981\/2013-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>Microstructural abnormalities in white matter (WM) are often reported in Alzheimer\u2019s disease (AD) and may reflect primary or secondary circuitry degeneration (i.e., due to cortical atrophy). The interpretation of diffusion tensor imaging (DTI) eigenvectors, known as multiple indices, may provide new insights into the main pathological models supporting primary or secondary patterns of WM disruption in AD, the retrogenesis, and Wallerian degeneration models, respectively. The aim of this review is to analyze the current literature on the contribution of DTI multiple indices to the understanding of AD neuropathology, taking the retrogenesis model as a reference for discussion. A systematic review using MEDLINE, EMBASE, and PUBMED was performed. Evidence suggests that AD evolves through distinct patterns of WM disruption, in which retrogenesis or, alternatively, the Wallerian degeneration may prevail. Distinct patterns of WM atrophy may be influenced by complex interactions which comprise disease status and progression, fiber localization, concurrent risk factors (i.e., vascular disease, gender), and cognitive reserve. The use of DTI multiple indices in addition to other standard multimodal methods in dementia research may help to determine the contribution of retrogenesis hypothesis to the understanding of neuropathological hallmarks that lead to AD.<\/jats:p>","DOI":"10.1155\/2015\/291658","type":"journal-article","created":{"date-parts":[[2015,1,20]],"date-time":"2015-01-20T21:00:53Z","timestamp":1421787653000},"page":"1-11","source":"Crossref","is-referenced-by-count":63,"title":["Integrating Retrogenesis Theory to Alzheimer\u2019s Disease Pathology: Insight from DTI-TBSS Investigation of the White Matter Microstructural Integrity"],"prefix":"10.1155","volume":"2015","author":[{"given":"Gilberto Sousa","family":"Alves","sequence":"first","affiliation":[{"name":"Translational Psychiatry Research Group, Department of Clinical Medicine, Federal University of Ceara, Rua Professor Costa Mendes 1608, 4\u00b0 Andar, Rodolfo Te\u00f3filo, 60430140 Fortaleza, CE, Brazil"},{"name":"Institute for General 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