{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T20:43:48Z","timestamp":1740170628583,"version":"3.37.3"},"reference-count":62,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. New-onset diabetes after transplantation (NODAT) is associated with decreased graft survival and an increased risk for cardiovascular disease. The objective of this study was to evaluate the risk factors for development of NODAT and its\u2019 relationship with arterial stiffness and left ventricular mass index (LVMI) in kidney transplant recipients.<jats:italic>Methods<\/jats:italic>. 159 kidney transplant recipients were selected from our transplantation center who underwent renal transplantation between years 2007 and 2010.<jats:italic>Results<\/jats:italic>. Among 159 patients, 57 (32.2%) patients were with NODAT who were significantly older than patients without diabetes (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>P<\/mml:mi><\/mml:mrow><\/mml:math>: 0.0001). Patients with NODAT had significantly higher pulse wave velocity (PWv) (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>P<\/mml:mi><\/mml:mrow><\/mml:math>: 0.033) and left ventricular mass index LVMI (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mi>P<\/mml:mi><\/mml:mrow><\/mml:math>: 0.001) compared to patients without NODAT. Further analysis was done according to LVMI as follows: LVMI &gt; 130\u2009g\/m<jats:sup>2<\/jats:sup>(<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mrow><mml:mi>n<\/mml:mi><\/mml:mrow><\/mml:math>: 57) and LVMI \u2264 130\u2009g\/m<jats:sup>2<\/jats:sup>(<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mrow><mml:mi>n<\/mml:mi><\/mml:mrow><\/mml:math>: 102). We observed higher office systolic and diastolic BP, serum trygliceride, glucose, creatinine, age, and HbA1c (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mrow><mml:mi>P<\/mml:mi><\/mml:mrow><\/mml:math>: 0.0001) levels in patients with LVMI &gt; 130\u2009g\/m<jats:sup>2<\/jats:sup>. Linear regression analysis revealed that HbA1c was the major determinant of LVMI (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mrow><mml:mi>P<\/mml:mi><\/mml:mrow><\/mml:math>: 0.026,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:mrow><mml:mi>\u03b2<\/mml:mi><\/mml:mrow><\/mml:math>: 0.361).<jats:italic>Conclusions<\/jats:italic>. HbA1c is the major determinant of LVMI, so strict control of serum glucose levels is essential for preventing cardiovascular disease in patients with NODAT.<\/jats:p>","DOI":"10.1155\/2015\/293896","type":"journal-article","created":{"date-parts":[[2015,4,8]],"date-time":"2015-04-08T11:42:31Z","timestamp":1428493351000},"page":"1-9","source":"Crossref","is-referenced-by-count":3,"title":["New-Onset Diabetes and Glucose Regulation Are Significant Determinants of Left Ventricular Hypertrophy in Renal Transplant Recipients"],"prefix":"10.1155","volume":"2015","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7326-8388","authenticated-orcid":true,"given":"Siren","family":"Sezer","sequence":"first","affiliation":[{"name":"Department of Nephrology, Baskent University Medical School, 06490 Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehtap","family":"Erkmen Uyar","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Baskent University 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