{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T04:03:10Z","timestamp":1773288190878,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61379136"],"award-info":[{"award-number":["61379136"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["SS2015AA02010"],"award-info":[{"award-number":["SS2015AA02010"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["KQCX20130628112914291"],"award-info":[{"award-number":["KQCX20130628112914291"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["GJHZ1212"],"award-info":[{"award-number":["GJHZ1212"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["JCYJ20130401170306884"],"award-info":[{"award-number":["JCYJ20130401170306884"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National High Technology Research and Development Program of China","award":["61379136"],"award-info":[{"award-number":["61379136"]}]},{"name":"National High Technology Research and Development Program of China","award":["SS2015AA02010"],"award-info":[{"award-number":["SS2015AA02010"]}]},{"name":"National High Technology Research and Development Program of China","award":["KQCX20130628112914291"],"award-info":[{"award-number":["KQCX20130628112914291"]}]},{"name":"National High Technology Research and Development Program of China","award":["GJHZ1212"],"award-info":[{"award-number":["GJHZ1212"]}]},{"name":"National High Technology Research and Development Program of China","award":["JCYJ20130401170306884"],"award-info":[{"award-number":["JCYJ20130401170306884"]}]},{"name":"Shenzhen Innovation Funding for Advance Talents","award":["61379136"],"award-info":[{"award-number":["61379136"]}]},{"name":"Shenzhen Innovation Funding for Advance Talents","award":["SS2015AA02010"],"award-info":[{"award-number":["SS2015AA02010"]}]},{"name":"Shenzhen Innovation Funding for Advance Talents","award":["KQCX20130628112914291"],"award-info":[{"award-number":["KQCX20130628112914291"]}]},{"name":"Shenzhen Innovation Funding for Advance Talents","award":["GJHZ1212"],"award-info":[{"award-number":["GJHZ1212"]}]},{"name":"Shenzhen Innovation Funding for Advance Talents","award":["JCYJ20130401170306884"],"award-info":[{"award-number":["JCYJ20130401170306884"]}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["61379136"],"award-info":[{"award-number":["61379136"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["SS2015AA02010"],"award-info":[{"award-number":["SS2015AA02010"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["KQCX20130628112914291"],"award-info":[{"award-number":["KQCX20130628112914291"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["GJHZ1212"],"award-info":[{"award-number":["GJHZ1212"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["JCYJ20130401170306884"],"award-info":[{"award-number":["JCYJ20130401170306884"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Basic Research Program of Shenzhen","award":["61379136"],"award-info":[{"award-number":["61379136"]}]},{"name":"Basic Research Program of Shenzhen","award":["SS2015AA02010"],"award-info":[{"award-number":["SS2015AA02010"]}]},{"name":"Basic Research Program of Shenzhen","award":["KQCX20130628112914291"],"award-info":[{"award-number":["KQCX20130628112914291"]}]},{"name":"Basic Research Program of Shenzhen","award":["GJHZ1212"],"award-info":[{"award-number":["GJHZ1212"]}]},{"name":"Basic Research Program of Shenzhen","award":["JCYJ20130401170306884"],"award-info":[{"award-number":["JCYJ20130401170306884"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computational and Mathematical Methods in Medicine"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>Existing models for predicting mortality based on traditional Cox proportional hazard approach (CPH) often have low prediction accuracy. This paper aims to develop a clinical risk model with good accuracy for predicting 1-year mortality in cardiac arrhythmias patients using random survival forest (RSF), a robust approach for survival analysis. 10,488 cardiac arrhythmias patients available in the public MIMIC II clinical database were investigated, with 3,452 deaths occurring within 1-year followups. Forty risk factors including demographics and clinical and laboratory information and antiarrhythmic agents were analyzed as potential predictors of all-cause mortality. RSF was adopted to build a comprehensive survival model and a simplified risk model composed of 14 top risk factors. The built comprehensive model achieved a prediction accuracy of 0.81 measured by c-statistic with 10-fold cross validation. The simplified risk model also achieved a good accuracy of 0.799. Both results outperformed traditional CPH (which achieved a c-statistic of 0.733 for the comprehensive model and 0.718 for the simplified model). Moreover, various factors are observed to have nonlinear impact on cardiac arrhythmias prognosis. As a result, RSF based model which took nonlinearity into account significantly outperformed traditional Cox proportional hazard model and has great potential to be a more effective approach for survival analysis.<\/jats:p>","DOI":"10.1155\/2015\/303250","type":"journal-article","created":{"date-parts":[[2015,8,25]],"date-time":"2015-08-25T21:24:10Z","timestamp":1440537850000},"page":"1-10","source":"Crossref","is-referenced-by-count":32,"title":["Risk Prediction of One-Year Mortality in Patients with Cardiac Arrhythmias Using Random Survival Forest"],"prefix":"10.1155","volume":"2015","author":[{"given":"Fen","family":"Miao","sequence":"first","affiliation":[{"name":"Key Laboratory for Health Informatics of the Chinese Academy of Sciences (HICAS), Shenzhen Institutes of Advanced Technology, Shenzhen 518055, China"},{"name":"Shenzhen College of Advanced Technology, University of Chinese Academy of Sciences, Beijing 100049, China"}]},{"given":"Yun-Peng","family":"Cai","sequence":"additional","affiliation":[{"name":"Key Laboratory for Health Informatics of the Chinese Academy of Sciences (HICAS), Shenzhen Institutes of Advanced Technology, Shenzhen 518055, China"}]},{"given":"Yu-Xiao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Senile Cardiovascular Medicine, The General Hospital of the People\u2019s Liberation Army, Beijing 100853, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5351-8546","authenticated-orcid":true,"given":"Ye","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory for Health Informatics of the Chinese Academy of Sciences (HICAS), Shenzhen Institutes of Advanced Technology, Shenzhen 518055, China"}]},{"given":"Yuan-Ting","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory for Health Informatics of the Chinese Academy of Sciences (HICAS), Shenzhen Institutes of Advanced Technology, Shenzhen 518055, China"},{"name":"Joint Research Centre for Biomedical Engineering, Department of Electronic Engineering, Chinese University of Hong Kong, Shatin 00852, Hong Kong"}]}],"member":"311","reference":[{"key":"1","year":"1995"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.105.584102"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp032"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfr030"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2011.10.071"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs337"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/504136"},{"issue":"3","key":"8","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1093\/oxfordjournals.aje.a114826","volume":"127","year":"1988","journal-title":"American Journal of Epidemiology"},{"issue":"2","key":"9","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.2517-6161.1972.tb00899.x","volume":"34","year":"1972","journal-title":"Journal of the Royal Statistical Society. Series B. Methodological"},{"issue":"2","key":"10","first-page":"123","volume":"24","year":"1996","journal-title":"Machine Learning"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1214\/aos\/1032181158"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2007.05.011"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa055643"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1001\/jama.298.17.2028"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.2.187"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1214\/08-aoas169"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.110.939371"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.eswa.2008.10.023"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1097\/ccm.0b013e31820a92c6"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.101.23.e215"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1080\/00949650212847"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4154"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/s0895-4356(01)00341-9"},{"key":"25","first-page":"88","volume":"88","year":"2003","journal-title":"Sports Science"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2004.01411.x"},{"issue":"2, article 305","key":"27","volume":"39","year":"2011","journal-title":"Critical Care Medicine"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.02.068"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2009.191"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2005.03.018"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1056\/nejm199103213241201"}],"container-title":["Computational and Mathematical Methods in Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2015\/303250.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2015\/303250.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2015\/303250.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T04:36:00Z","timestamp":1748579760000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/cmmm\/2015\/303250\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":30,"alternative-id":["303250","303250"],"URL":"https:\/\/doi.org\/10.1155\/2015\/303250","relation":{},"ISSN":["1748-670X","1748-6718"],"issn-type":[{"value":"1748-670X","type":"print"},{"value":"1748-6718","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}