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Three-month-old Sprague-Dawley male rats were divided into 4 groups: (1) baseline, (2) normal diet for 4 weeks, (3) calcium-deprived diet for 4 weeks, and (4) calcium-deprived diet for 4 weeks and concomitant administration of PTH (1-34) 40\u2009<jats:italic>\u00b5<\/jats:italic>g\/Kg\/day. Histomorphometrical analyses were made on cortical and trabecular bone of lumbar vertebral body as well as of mid-diaphysis and distal metaphysis of femur. In all rats fed calcium-deprived diet, despite the reduction of trabecular number (due to the maintenance of mineral homeostasis), an intense activity of bone deposition occurs on the surface of the few remaining trabeculae (in answering to mechanical stresses and, consequently, to maintain the skeletal homeostasis). Different responses were detected in different sites of cortical bone, depending on their main function in answering mineral or skeletal homeostasis. This study represents the starting point for work-in-progress researches, with the aim of defining in detail timing and manners of evolution and recovery of biochemical osteoporosis.<\/jats:p>","DOI":"10.1155\/2015\/304178","type":"journal-article","created":{"date-parts":[[2015,5,4]],"date-time":"2015-05-04T21:04:01Z","timestamp":1430773441000},"page":"1-12","source":"Crossref","is-referenced-by-count":10,"title":["Mineral and Skeletal Homeostasis Influence the Manner of Bone Loss in Metabolic Osteoporosis due to Calcium-Deprived Diet in Different Sites of Rat Vertebra and Femur"],"prefix":"10.1155","volume":"2015","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0280-3598","authenticated-orcid":true,"given":"Marzia","family":"Ferretti","sequence":"first","affiliation":[{"name":"Dipartimento di Scienze Biomediche, Metaboliche e Neuroscienze-Sezione di Morfologia Umana, Universit\u00e0 di Modena e Reggio Emilia, Istituti Anatomici, 41124 Modena, 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