{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T10:38:17Z","timestamp":1756636697548},"reference-count":48,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2015,8,19]],"date-time":"2015-08-19T00:00:00Z","timestamp":1439942400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Allergy"],"published-print":{"date-parts":[[2015,8,19]]},"abstract":"<jats:p>Asthma is one of the most common respiratory diseases affecting all age groups. The world is now trying to identify some dietary factors which can play a preventive role. We performed this systematic review and meta-analysis of RCTs to assess the effect of intake of polyunsaturated fatty acid (PUFA) in infancy and\/or childhood on incidence of asthma or wheezing episodes. We searched MEDLINE, EBSCO, Trip, and Google Scholar up to January 31, 2015. All RCTs where infants or children who were given omega-3 fatty acid supplementation and which reported incidence of asthma and\/or wheezing episodes as dichotomous outcomes were included in this review. Random effects model was used for pooling the risk estimates. Total five articles were included. Most of them were from Australia. On meta-analysis, the pooled estimate of odds ratios by random effects model showed no significant change in incidence of asthma after supplementation of omega-3 FA in infancy or childhood (OR 0.974; CI 0.646, 1.469; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.900<\/mml:mn><\/mml:math>).  We concluded that a multicentric RCT is required to assess the effect of omega-3 FA supplementation exclusively to infants or children to predict the best time of omega-3 FA supplementation to prevent asthmatic or wheezing episodes later in life.<\/jats:p>","DOI":"10.1155\/2015\/312052","type":"journal-article","created":{"date-parts":[[2015,8,19]],"date-time":"2015-08-19T21:03:15Z","timestamp":1440018195000},"page":"1-7","source":"Crossref","is-referenced-by-count":23,"title":["Omega-3 Fatty Acids Supplementation in Children to Prevent Asthma: Is It Worthy?\u2014A Systematic Review and Meta-Analysis"],"prefix":"10.1155","volume":"2015","author":[{"given":"Prasad","family":"Muley","sequence":"first","affiliation":[{"name":"Department of Paediatrics, S.B.K.S MIRC, Sumandeep Vidyapeeth, Vadodara, Gujarat 391760, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monali","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Periodontics, K.M.S 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