{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T18:19:37Z","timestamp":1791137977448,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Zhejiang Province Natural Science Foundation","award":["Y2110550"],"award-info":[{"award-number":["Y2110550"]}]},{"name":"Zhejiang Province Natural Science Foundation","award":["LY13H310006"],"award-info":[{"award-number":["LY13H310006"]}]},{"name":"Zhejiang Province Natural Science Foundation","award":["LY13H020004"],"award-info":[{"award-number":["LY13H020004"]}]},{"name":"Zhejiang Province Natural Science Foundation","award":["Y2110550"],"award-info":[{"award-number":["Y2110550"]}]},{"name":"Zhejiang Province Natural Science Foundation","award":["LY13H310006"],"award-info":[{"award-number":["LY13H310006"]}]},{"name":"Zhejiang Province Natural Science Foundation","award":["LY13H020004"],"award-info":[{"award-number":["LY13H020004"]}]},{"name":"Zhejiang Province Natural Science Foundation","award":["Y2110550"],"award-info":[{"award-number":["Y2110550"]}]},{"name":"Zhejiang Province Natural Science Foundation","award":["LY13H310006"],"award-info":[{"award-number":["LY13H310006"]}]},{"name":"Zhejiang Province Natural Science Foundation","award":["LY13H020004"],"award-info":[{"award-number":["LY13H020004"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    . Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine. This study explored the association of 173G\/C polymorphism of the MIF gene with coronary heart disease (CHD).\n                    <jats:italic>Methods<\/jats:italic>\n                    . Sequencing was carried out after polymerase chain reaction with DNA specimens from 186 volunteers without CHD and 70 patients with CHD. Plasma MIF levels on admission were measured by ELISA. Patients were classified into either stable angina pectoris (SAP) or unstable angina pectoris (UAP). Genotype distribution between cases and controls and the association of patients\u2019 genotypes with MIF level and plaque stability were statistically evaluated (ethical approval number: 2012-01).\n                    <jats:italic>Results<\/jats:italic>\n                    . The frequency of the C genotype was higher in CHD patients than in the control (\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                      <mml:mi>P<\/mml:mi>\n                      <mml:mo>=<\/mml:mo>\n                      <mml:mn>0.014<\/mml:mn>\n                    <\/mml:math>\n                    ). The frequency of the 173\n                    <jats:sup>*<\/jats:sup>\n                    CC genotype was higher in CHD patients than in the control (\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                      <mml:mi>P<\/mml:mi>\n                      <mml:mo>=<\/mml:mo>\n                      <mml:mn>0.005<\/mml:mn>\n                    <\/mml:math>\n                    ). The plasma MIF level was higher in MIF173\n                    <jats:sup>*<\/jats:sup>\n                    C carriers than in MIF173\n                    <jats:sup>*<\/jats:sup>\n                    G carriers (\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                      <mml:mi>P<\/mml:mi>\n                      <mml:mo>=<\/mml:mo>\n                      <mml:mn>0.033<\/mml:mn>\n                    <\/mml:math>\n                    ). CHD patients had higher plasma MIF levels than the control (\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                      <mml:mi>P<\/mml:mi>\n                      <mml:mo>=<\/mml:mo>\n                      <mml:mn>0.000<\/mml:mn>\n                    <\/mml:math>\n                    ). Patients with UAP had higher plasma MIF levels than patients with SAP (\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                      <mml:mi>P<\/mml:mi>\n                      <mml:mo>=<\/mml:mo>\n                      <mml:mn>0.014<\/mml:mn>\n                    <\/mml:math>\n                    ).\n                    <jats:italic>Conclusions<\/jats:italic>\n                    . These data suggest that MIF \u2212173G\/C polymorphism may be related to the development of CHD in a Chinese population. Plasma MIF level is a predictor of plaque stability. This trial is registered with\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/clinicaltrials.gov\/show\/NCT01750502\">NCT01750502<\/jats:ext-link>\n                    .\n                  <\/jats:p>","DOI":"10.1155\/2015\/315174","type":"journal-article","created":{"date-parts":[[2015,3,4]],"date-time":"2015-03-04T16:00:53Z","timestamp":1425484853000},"page":"1-6","source":"Crossref","is-referenced-by-count":14,"title":["Macrophage Migration Inhibitory Factor Polymorphism Is Associated with Susceptibility to Inflammatory Coronary Heart Disease"],"prefix":"10.1155","volume":"2015","author":[{"given":"Kangting","family":"Ji","sequence":"first","affiliation":[{"name":"Department of Cardiology, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou 325000, 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