{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T19:26:52Z","timestamp":1789586812927,"version":"build-2803163510"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pain Research and Management"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:p>BACKGROUND: The efficacy of opioids for acute pain relief in the emergency department (ED) is well recognized, but treatment with opioids is associated with adverse events ranging from minor discomforts to life\u2010threatening events.<\/jats:p><jats:p>OBJECTIVE: To assess the impact of age, sex and route of administration on the incidence of adverse events due to opioid administration in the ED.<\/jats:p><jats:p>METHODS: Real\u2010time archived data were analyzed retrospectively in a tertiary care urban hospital. All consecutive patients (\u226516 years of age) who were assigned to an ED bed and received an opioid between March 2008 and December 2012 were included. Adverse events were defined as: nausea\/vomiting (minor); systolic blood pressure (SBP) &lt; 90 mmHg, oxygen saturation (Sat) &lt; 92% and respiration rate &lt; 10 breaths\/min (major) within 2 h of the first opioid doses.<\/jats:p><jats:p>RESULTS: In the study period, 31,742 patients were treated with opioids. The mean (\u00b1  SD) age was 55.8\u00b1 20.5 years, and 53% were female. The overall incidence of adverse events was 12.0% (95% CI 11.6% to 12.4%): 5.9% (95% CI 5.6% to 6.2%) experienced nausea\/vomiting, 2.4% (95% CI 2.2% to 2.6%) SBP &lt; 90 mmHg, 4.7% (95% CI 4.5% to 4.9%) Sat that dropped to &lt; 92% and 0.09% respiration rate &lt; 10 breaths\/min. After controlling for confounding factors, these adverse events were associated with: female sex (more nausea\/vomiting, more SBP &lt; 90 mmHg, less Sat &lt; 92%); age \u226565 years (less nausea\/vomiting, more SBP &lt; 90 mmHg, more Sat &lt; 92%); and route of administration (intravenous &gt; subcutaneous &gt; oral).<\/jats:p><jats:p>CONCLUSIONS: The incidence of adverse events associated with opioid administration in the ED is generally low and is associated with age, sex and route of administration.<\/jats:p>","DOI":"10.1155\/2015\/316275","type":"journal-article","created":{"date-parts":[[2016,3,15]],"date-time":"2016-03-15T07:40:52Z","timestamp":1458027652000},"page":"23-28","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Impact of Age, Sex and Route of Administration on Adverse Events after Opioid Treatment in the Emergency Department: A Retrospective Study"],"prefix":"10.1155","volume":"20","author":[{"given":"Raoul","family":"Daoust","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Paquet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Lavigne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9ric","family":"Piette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marc","family":"Chauny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,1]]},"container-title":["Pain Research and Management"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/prm\/2015\/316275.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2015\/316275","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T14:18:32Z","timestamp":1723126712000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2015\/316275"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1155\/2015\/316275"],"URL":"https:\/\/doi.org\/10.1155\/2015\/316275","archive":["Portico"],"relation":{},"ISSN":["1203-6765","1918-1523"],"issn-type":[{"value":"1203-6765","type":"print"},{"value":"1918-1523","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1]]},"assertion":[{"value":"2015-01-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}