{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:38:45Z","timestamp":1790948325719,"version":"4.1.0"},"reference-count":21,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p><jats:italic>Purpose.<\/jats:italic>To evaluate effectiveness of simultaneous topography-guided photorefractive keratectomy and corneal collagen cross-linking in mild and moderate keratoconus.<jats:italic>Methods<\/jats:italic>. Prospective nonrandomized interventional study including 20 eyes of 14 patients with grade 1-2 keratoconus that underwent topography-guided PRK using a Custom Ablation Transition Zone (CATz) profile with 0.02% MMC application immediately followed by standard 3\u2009mw\/cm<jats:sup>2<\/jats:sup>UVA collagen cross-linking. Maximum ablation depth did not exceed 58\u2009<jats:italic>\u03bc<\/jats:italic>m. Follow-up period: 12 months.<jats:italic>Results.<\/jats:italic>Progressive statistically significant improvement of UCVA from<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mn>0.83<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>0.37<\/mml:mn><\/mml:math>logMAR preoperative, reaching<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mn>0.25<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>0.26<\/mml:mn><\/mml:math>logMAR at 12 months (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>). Preoperative BCVA (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mn>0.27<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>0.31<\/mml:mn><\/mml:math>logMAR) showed a progressive improvement reaching<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mn>0.08<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>0.12<\/mml:mn><\/mml:math>logMAR at 12 months (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.02<\/mml:mn><\/mml:math>). Mean<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mrow><mml:mi>K<\/mml:mi><\/mml:mrow><\/mml:math>max reduced from<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:mn>48.9<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>2.8<\/mml:mn><\/mml:math>to<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\"><mml:mn>45.4<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>3.1<\/mml:mn><\/mml:math>\u2009D at 12 months (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M10\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>), mean<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M11\"><mml:mrow><mml:mi>K<\/mml:mi><\/mml:mrow><\/mml:math>min reduced from<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M12\"><mml:mn>45.9<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>2.8<\/mml:mn><\/mml:math>\u2009D to<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M13\"><mml:mn>44.1<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>3.2<\/mml:mn><\/mml:math>\u2009D at 12 months (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M14\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.003<\/mml:mn><\/mml:math>), mean keratometric asymmetry reduced from<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M15\"><mml:mn>3.01<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>2.03<\/mml:mn><\/mml:math>\u2009D to<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M16\"><mml:mn>1.25<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>1.2<\/mml:mn><\/mml:math>\u2009D at 12 months (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M17\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>). The safety index was 1.39 at 12 months and efficacy index 0.97 at 12 months.<jats:italic>Conclusion<\/jats:italic>. Combined topography-guided PRK and corneal collagen cross-linking are a safe and effective option in the management of mild and moderate keratoconus.<jats:italic>Precis<\/jats:italic>. To our knowledge, this is the first published study on the use of the CATz ablation system on the Nidek Quest excimer laser platform combined with conventional cross-linking in the management of mild keratoconus.<\/jats:p>","DOI":"10.1155\/2015\/321953","type":"journal-article","created":{"date-parts":[[2015,8,23]],"date-time":"2015-08-23T21:23:17Z","timestamp":1440364997000},"page":"1-7","source":"Crossref","is-referenced-by-count":13,"title":["One-Year Results of Simultaneous Topography-Guided Photorefractive Keratectomy and Corneal Collagen Cross-Linking in Keratoconus Utilizing a Modern Ablation Software"],"prefix":"10.1155","volume":"2015","author":[{"given":"A. M.","family":"Sherif","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine, Cairo University, Cairo 12411, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. A.","family":"Ammar","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine, Cairo University, Cairo 12411, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y. S.","family":"Mostafa","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine, Cairo University, Cairo 12411, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. A.","family":"Gamal Eldin","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine, Cairo University, Cairo 12411, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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