{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T00:56:13Z","timestamp":1793321773371,"version":"4.5.0"},"reference-count":25,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Endocrinology"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>To assess the prevalence of osteoporosis in young men with hypogonadotropic hypogonadism (HH) and to investigate the changes of BMD and metabolic parameters, a total of 22 young male patients with HH and 20 healthy controls were enrolled in the study. BMD, biochemical, and hormonal parameters were measured in two groups. Osteoporosis was more prevalent in HH patients (45.45%) than the control subjects (10.00%) (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>). The patients with HH had lower BMD in lumbar spine 2\u20134, femoral neck, and total hip (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>, for all) and higher fasting insulin (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>), HOMA-IR (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.002<\/mml:mn><\/mml:math>), and SHBG (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>) compared to the controls. After 6 months of pulsatile gonadorelin treatment, BMI (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.021<\/mml:mn><\/mml:math>) and BMD in lumbar spine 2\u20134, femoral neck, and total hip (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.002<\/mml:mn><\/mml:math>,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.003<\/mml:mn><\/mml:math>, and<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.003<\/mml:mn><\/mml:math>, resp.) increased dramatically and total cholesterol (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M10\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.034<\/mml:mn><\/mml:math>), fasting insulin (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M11\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.025<\/mml:mn><\/mml:math>), HOMA-IR (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M12\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.021<\/mml:mn><\/mml:math>), and SHBG (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M13\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>) decreased significantly in HH patients. The study shows a higher prevalence of osteoporosis in young men with HH. Long-term pulsatile gonadorelin treatment indicates a positive effect on BMD and metabolic parameters of HH patients.<\/jats:p>","DOI":"10.1155\/2015\/324524","type":"journal-article","created":{"date-parts":[[2015,8,31]],"date-time":"2015-08-31T17:49:00Z","timestamp":1441043340000},"page":"1-5","source":"Crossref","is-referenced-by-count":9,"title":["Changes in Bone Mineral Density and Metabolic Parameters after Pulsatile Gonadorelin Treatment in Young Men with Hypogonadotropic Hypogonadism"],"prefix":"10.1155","volume":"2015","author":[{"given":"Chen-Xi","family":"Li","sequence":"first","affiliation":[{"name":"Department of Endocrine and Metabolic Diseases, The First Affiliated Hospital of Anhui Medical University, Hefei 230032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song-Tao","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Endocrine and Metabolic Diseases, The First Affiliated Hospital of Anhui Medical University, Hefei 230032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0204-3528","authenticated-orcid":true,"given":"Qiu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrine and Metabolic Diseases, The First Affiliated Hospital of Anhui Medical University, Hefei 230032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2013(sup01)09"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1490601"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1097\/mou.0000000000000104"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2014.10.005"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2009.03746.x"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-70-1-3"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-69-4-776"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12135"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-51-1-173"},{"issue":"11","key":"10","first-page":"1263","volume":"129","year":"2001","journal-title":"Revista Medica de Chile"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocd.2014.01.005"},{"key":"12","first-page":"1","volume":"921","year":"2003","journal-title":"World Health Organization Technical Report Series"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1007\/pl00004148"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-1402"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2005.00337.x"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.1.66"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-014-0187-1"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2011.03482.x"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2010.03.011"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.4158\/ep.13.6.629"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1530\/eje-10-0951"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0119995"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2013.09.017"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.12319"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1510415"}],"container-title":["International Journal of Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ije\/2015\/324524.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ije\/2015\/324524.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ije\/2015\/324524.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,7,27]],"date-time":"2016-07-27T14:02:18Z","timestamp":1469628138000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/ije\/2015\/324524\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":25,"alternative-id":["324524","324524"],"URL":"https:\/\/doi.org\/10.1155\/2015\/324524","relation":{},"ISSN":["1687-8337","1687-8345"],"issn-type":[{"value":"1687-8337","type":"print"},{"value":"1687-8345","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}