{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:48:00Z","timestamp":1753886880735,"version":"3.41.2"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,5,21]],"date-time":"2015-05-21T00:00:00Z","timestamp":1432166400000},"content-version":"vor","delay-in-days":140,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Scientific World Journal"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:p>The high incidence of tumor recurrence following transurethral resection (TUR) represents a major problem encountered in the management of bladder cancer. This study examined the efficacy of intravesical chemotherapy in superficial bladder cancer. We retrospectively analyzed 90 Japanese cases with low\u2010grade superficial transitional cell carcinoma (stage T1, grades 1 and 2) who were rendered tumor\u2010free by TURBT (TUR of bladder tumor) and who thereafter were treated with or without intravesical chemotherapy. Among them, instillation was terminated in 2 patients due to adverse effects (severe but reversible chemical cystitis). Remaining 88 patients were divided into 2 groups according to therapy: the TURBT\u2010only group (<jats:italic>n<\/jats:italic> = 46), defined as patients treated with TURBT alone, and the Instillation group (<jats:italic>n<\/jats:italic> = 42), defined as patients treated with weekly intravesical instillation therapies using epirubicin plus Ara\u2010C. Recurrence\u2010free rate was significantly higher in the Instillation group than in the TURBT\u2010only group (<jats:italic>p<\/jats:italic> = 0.02, HR = 0.457). The 5\u2010year recurrence\u2010free rate was 58.5% for the Instillation group and 38.6% for the TURBT\u2010only group. Our instillation schedule represents the most intensive regimen among previously reported therapies and resulted in a 54.3% decrease in incidence of tumor recurrence. We believe that the results of this study could provide useful information on management of bladder cancer.<\/jats:p>","DOI":"10.1155\/2015\/325305","type":"journal-article","created":{"date-parts":[[2015,5,25]],"date-time":"2015-05-25T21:04:13Z","timestamp":1432587853000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Analysis of Japanese Patients Treated with or without Long\u2010Term Epirubicin Plus Ara\u2010C Intravesical Instillation Therapy for Low\u2010Grade Superficial Bladder Cancer"],"prefix":"10.1155","volume":"2015","author":[{"given":"Tomonori","family":"Kato","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazushi","family":"Nomura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fukuo","family":"Kondo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masami","family":"Wakisaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Komiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,5,21]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_8_1_2","DOI":"10.1002\/(SICI)1098-2388(199709\/10)13:5&lt;335::AID-SSU7>3.0.CO;2-E"},{"doi-asserted-by":"publisher","key":"e_1_2_8_2_2","DOI":"10.1097\/00005392-199707000-00018"},{"doi-asserted-by":"publisher","key":"e_1_2_8_3_2","DOI":"10.1016\/s0022-5347(01)66226-8"},{"doi-asserted-by":"publisher","key":"e_1_2_8_4_2","DOI":"10.1016\/S0022-5347(17)36198-0"},{"doi-asserted-by":"publisher","key":"e_1_2_8_5_2","DOI":"10.1016\/s0022-5347(01)61606-9"},{"doi-asserted-by":"publisher","key":"e_1_2_8_6_2","DOI":"10.1016\/s0022-5347(05)64556-9"},{"doi-asserted-by":"publisher","key":"e_1_2_8_7_2","DOI":"10.1200\/JCO.1986.4.3.425"},{"doi-asserted-by":"publisher","key":"e_1_2_8_8_2","DOI":"10.1620\/tjem.136.23"},{"doi-asserted-by":"publisher","key":"e_1_2_8_9_2","DOI":"10.1016\/s1078-1439(99)00015-0"},{"doi-asserted-by":"publisher","key":"e_1_2_8_10_2","DOI":"10.1097\/01.ju.0000100386.07370.0a"},{"doi-asserted-by":"publisher","key":"e_1_2_8_11_2","DOI":"10.1016\/s0895-4356(99)00203-6"},{"doi-asserted-by":"publisher","key":"e_1_2_8_12_2","DOI":"10.1046\/j.1464-410x.2003.04360.x"},{"doi-asserted-by":"publisher","key":"e_1_2_8_13_2","DOI":"10.1016\/j.eururo.2013.06.009"}],"container-title":["The Scientific World Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/tswj\/2015\/325305.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/tswj\/2015\/325305.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2015\/325305","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T01:00:04Z","timestamp":1722906004000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2015\/325305"}},"subtitle":[],"editor":[{"given":"Ronald M.","family":"Bukowski","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1155\/2015\/325305"],"URL":"https:\/\/doi.org\/10.1155\/2015\/325305","archive":["Portico"],"relation":{},"ISSN":["2356-6140","1537-744X"],"issn-type":[{"type":"print","value":"2356-6140"},{"type":"electronic","value":"1537-744X"}],"subject":[],"published":{"date-parts":[[2015,1]]},"assertion":[{"value":"2014-09-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-03-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-05-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"325305"}}