{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T17:22:14Z","timestamp":1770484934070,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>This study shows the evaluation the antiproliferative effect of the extract, fractions, and uncommon compounds isolated from<jats:italic>R. rosaefolius<\/jats:italic>leaves. The compounds were identified by conventional spectroscopic methods such as NMR-H<jats:sup>1<\/jats:sup>and C<jats:sup>13<\/jats:sup>and identified as 5,7-dihydroxy-6,8,4\u2032-trimethoxyflavonol (<jats:bold>1<\/jats:bold>), 5-hydroxy-3,6,7,8,4\u2032-pentamethoxyflavone (<jats:bold>2<\/jats:bold>), and tormentic acid (<jats:bold>3<\/jats:bold>). Both hexane and dichloromethane fractions showed selectivity for multidrug-resistant ovary cancer cell line (NCI-ADR\/RES) with total growth inhibition values of 11.1 and 12.6\u2009<jats:italic>\u03bc<\/jats:italic>g\/ml, respectively. Compound<jats:bold>1<\/jats:bold>also showed selective activity against the same cell line (18.8\u2009<jats:italic>\u03bc<\/jats:italic>g\/ml); however, it was especially effective against glioma cells (2.8\u2009<jats:italic>\u03bc<\/jats:italic>g\/ml), suggesting that this compound may be involved with the<jats:italic>in vitro<\/jats:italic>antiproliferative action.<\/jats:p>","DOI":"10.1155\/2015\/341216","type":"journal-article","created":{"date-parts":[[2015,12,14]],"date-time":"2015-12-14T21:00:39Z","timestamp":1450126839000},"page":"1-6","source":"Crossref","is-referenced-by-count":11,"title":["Uncommon Trimethoxylated Flavonol Obtained from<i>Rubus rosaefolius<\/i>Leaves and Its Antiproliferative Activity"],"prefix":"10.1155","volume":"2015","author":[{"given":"Marcel","family":"Petreanu","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas, N\u00facleo de Investiga\u00e7\u00f5es Qu\u00edmico-Farmac\u00eauticas (NIQFAR), Universidade do Vale do Itaja\u00ed (UNIVALI), 88302-901 Itaja\u00ed, SC, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emili Kamila","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas, N\u00facleo de Investiga\u00e7\u00f5es Qu\u00edmico-Farmac\u00eauticas (NIQFAR), Universidade do Vale do Itaja\u00ed (UNIVALI), 88302-901 Itaja\u00ed, SC, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Paula M.","family":"Sagaz","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas, N\u00facleo de Investiga\u00e7\u00f5es Qu\u00edmico-Farmac\u00eauticas (NIQFAR), Universidade do Vale do Itaja\u00ed (UNIVALI), 88302-901 Itaja\u00ed, SC, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u00e9bora B.","family":"Vendramini-Costa","sequence":"additional","affiliation":[{"name":"Centro Pluridisciplinar de Pesquisas Qu\u00edmicas, Biol\u00f3gicas e Agr\u00edcolas (CPQBA), Universidade Estadual de Campinas (UNICAMP), 13083-970 Campinas, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana L\u00facia T. 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