{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:21:19Z","timestamp":1790788879204,"version":"4.1.0"},"reference-count":55,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2015]]},"abstract":"The main cause of death in rheumatoid arthritis (RA) is cardiovascular events. We evaluated the relationship of anticyclic citrullinated peptide (anti-CCP) antibody levels with increased carotid intima-media thickness (cIMT) in RA patients.Methods<\/jats:italic>. Forty-five anti-CCP positive and 37 anti-CCP negative RA patients, and 62 healthy controls (HC) were studied. All groups were assessed for atherogenic index of plasma (AIP) and cIMT. Anti-CCP, C-reactive protein (CRP), and levels of tumor necrosis factor alpha (TNF\u03b1<\/jats:italic>) and interleukin-6 (IL-6) were measured by enzyme-linked immunosorbent assay (ELISA).Results<\/jats:italic>. The anti-CCP positive RA patients showed increased cIMT compared to HC and anti-CCP negative (P<\/mml:mi><<\/mml:mo>0.001<\/mml:mn><\/mml:math>). Anti-CCP positive versus anti-CCP negative RA patients, had increased AIP, TNF\u03b1<\/jats:italic>and IL-6 (P<\/mml:mi><<\/mml:mo>0.01<\/mml:mn><\/mml:math>), and lower levels of high density lipoprotein cholesterol (HDL-c) (P<\/mml:mi>=<\/mml:mo>0.02<\/mml:mn><\/mml:math>). The cIMT correlated with levels of anti-CCP (r<\/mml:mi>=<\/mml:mo>0.513<\/mml:mn><\/mml:math>,P<\/mml:mi>=<\/mml:mo>0.001<\/mml:mn><\/mml:math>), CRP (r<\/mml:mi>=<\/mml:mo>0.799<\/mml:mn><\/mml:math>,P<\/mml:mi><<\/mml:mo>0.001<\/mml:mn><\/mml:math>), TNF\u03b1<\/jats:italic>(r<\/mml:mi>=<\/mml:mo>0.642<\/mml:mn><\/mml:math>,P<\/mml:mi>=<\/mml:mo>0.001<\/mml:mn><\/mml:math>), and IL-6 (r<\/mml:mi>=<\/mml:mo>0.751<\/mml:mn><\/mml:math>,P<\/mml:mi><<\/mml:mo>0.001<\/mml:mn><\/mml:math>). In multiple regression analysis, cIMT was associated with CRP (P<\/mml:mi><<\/mml:mo>0.001<\/mml:mn><\/mml:math>) and anti-CCP levels (P<\/mml:mi>=<\/mml:mo>0.03<\/mml:mn><\/mml:math>).Conclusions<\/jats:italic>. Levels of anti-CCP and CRP are associated with increased cIMT and cardiovascular risk supporting a clinical role of the measurement of cIMT in RA in predicting and preventing cardiovascular events.<\/jats:p>","DOI":"10.1155\/2015\/342649","type":"journal-article","created":{"date-parts":[[2015,3,2]],"date-time":"2015-03-02T16:01:21Z","timestamp":1425312081000},"page":"1-10","source":"Crossref","is-referenced-by-count":20,"title":["Serum Levels of Anticyclic Citrullinated Peptide Antibodies, Interleukin-6, Tumor Necrosis Factor-\u03b1<\/i>, and C-Reactive Protein Are Associated with Increased Carotid Intima-Media Thickness: A Cross-Sectional Analysis of a Cohort of Rheumatoid Arthritis Patients without Cardiovascular Risk Factors"],"prefix":"10.1155","volume":"2015","author":[{"given":"M\u00f3nica","family":"V\u00e1zquez-Del Mercado","sequence":"first","affiliation":[{"name":"Instituto de Investigaci\u00f3n en Reumatolog\u00eda y del Sistema M\u00fasculo Esquel\u00e9tico, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada No. 950, Colonia Independencia, 44340 Guadalajara, JAL, Mexico"},{"name":"Departamento de Reumatolog\u00eda, Hospital Civil \u201cDr. Juan I. Menchaca\u201d, Universidad de Guadalajara, Salvador de Quevedo No. 750, 44100 Guadalajara, JAL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lourdes","family":"Nu\u00f1ez-Atahualpa","sequence":"additional","affiliation":[{"name":"Hospital Civil de Guadalajara \u201cFray Antonio Alcalde\u201d, Universidad de Guadalajara, Hospital No. 278, 44280 Guadalajara, JAL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio","family":"Figueroa-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Hospital Civil de Guadalajara \u201cFray Antonio Alcalde\u201d, Universidad de Guadalajara, Hospital No. 278, 44280 Guadalajara, JAL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"G\u00f3mez-Ba\u00f1uelos","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n en Reumatolog\u00eda y del Sistema M\u00fasculo Esquel\u00e9tico, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada No. 950, Colonia Independencia, 44340 Guadalajara, JAL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto Daniel","family":"Rocha-Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n en Reumatolog\u00eda y del Sistema M\u00fasculo Esquel\u00e9tico, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada No. 950, Colonia Independencia, 44340 Guadalajara, JAL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz Teresita","family":"Mart\u00edn-M\u00e1rquez","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n en Reumatolog\u00eda y del Sistema M\u00fasculo Esquel\u00e9tico, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada No. 950, Colonia Independencia, 44340 Guadalajara, JAL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6540-2444","authenticated-orcid":true,"given":"Esther Guadalupe","family":"Corona-Sanchez","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n en Reumatolog\u00eda y del Sistema M\u00fasculo Esquel\u00e9tico, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada No. 950, Colonia Independencia, 44340 Guadalajara, JAL, Mexico"},{"name":"Departamento de Fisiolog\u00eda, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada No. 950, Colonia Independencia, 44340 Guadalajara, JAL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika Aurora","family":"Mart\u00ednez-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n en Reumatolog\u00eda y del Sistema M\u00fasculo Esquel\u00e9tico, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada No. 950, Colonia Independencia, 44340 Guadalajara, JAL, Mexico"},{"name":"Departamento de Fisiolog\u00eda, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada No. 950, Colonia Independencia, 44340 Guadalajara, JAL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9ctor","family":"Macias-Reyes","sequence":"additional","affiliation":[{"name":"Hospital Civil de Guadalajara \u201cFray Antonio Alcalde\u201d, Universidad de Guadalajara, Hospital No. 278, 44280 Guadalajara, JAL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6517-6344","authenticated-orcid":true,"given":"Laura","family":"Gonzalez-Lopez","sequence":"additional","affiliation":[{"name":"Departamento de Medicina Interna-Reumatolog\u00eda, Hospital General Regional No. 110, Instituto Mexicano del Seguro Social, Circunvalaci\u00f3n Oblatos No. 2212, Colonia Oblatos, 44700 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