{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T12:30:59Z","timestamp":1773923459254,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["MS\/CNPq\/FDCT-FUNTAC\/SESACRE 2013"],"award-info":[{"award-number":["MS\/CNPq\/FDCT-FUNTAC\/SESACRE 2013"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Acre","award":["MS\/CNPq\/FDCT-FUNTAC\/SESACRE 2013"],"award-info":[{"award-number":["MS\/CNPq\/FDCT-FUNTAC\/SESACRE 2013"]}]},{"name":"Universidade Federal do Acre","award":["MS\/CNPq\/FDCT-FUNTAC\/SESACRE 2013"],"award-info":[{"award-number":["MS\/CNPq\/FDCT-FUNTAC\/SESACRE 2013"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Interdisciplinary Perspectives on Infectious Diseases"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>Side effects of antimalarial drug can overlap with malaria symptoms. We evaluated 50 patients with<jats:italic>vivax<\/jats:italic>malaria in M\u00e2ncio Lima, Acre, treated with chloroquine and primaquine. Patients were evaluated for the presence of 21 symptoms before and after treatment and for reported side effects of these drugs after treatment was started. The most frequent symptoms before medication were headache, fever, chills, sweating, arthralgia, back pain, and weakness, which were present in between 40% and 76% of respondents. The treatment reduced the occurrence of these symptoms and reduced the lack of appetite, but gastrointestinal symptoms and choluria increased in frequency. There were no reports of pale stools before medication, but 12% reported the occurrence of this symptom after treatment started. Other symptoms such as blurred vision (54%), pruritus (22%), paresthesia (6%), insomnia (46%), and \u201cstings\u201d into the skin (22%) were reported after chloroquine was taken. The antimalarial drugs used to treat<jats:italic>P. vivax<\/jats:italic>malaria reduce much of the systemic and algic symptoms but cause mainly gastrointestinal side effects that may lead to lack of adherence to drug treatment. It is important to guide the patient for the appearance and the transience of such side effects in order to avoid abandoning treatment.<\/jats:p>","DOI":"10.1155\/2015\/346853","type":"journal-article","created":{"date-parts":[[2015,8,18]],"date-time":"2015-08-18T21:02:18Z","timestamp":1439931738000},"page":"1-7","source":"Crossref","is-referenced-by-count":50,"title":["Side Effects of Chloroquine and Primaquine and Symptom Reduction in Malaria Endemic Area (M\u00e2ncio Lima, Acre, Brazil)"],"prefix":"10.1155","volume":"2015","author":[{"given":"C\u00e1ssio Braga e","family":"Braga","sequence":"first","affiliation":[{"name":"Centro de Ci\u00eancias da Sa\u00fade e do Desporto, Universidade Federal do Acre, Campus Universit\u00e1rio, BR 364, Km 04, 69920-900 Rio Branco, AC, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio Camargo","family":"Martins","sequence":"additional","affiliation":[{"name":"Centro de Ci\u00eancias da Sa\u00fade e do Desporto, 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