{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T16:24:30Z","timestamp":1791563070566,"version":"4.3.4"},"reference-count":14,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Memory Ageing and Cognition Centre","award":["NMRC\/CG\/NUHS\/2010"],"award-info":[{"award-number":["NMRC\/CG\/NUHS\/2010"]}]},{"DOI":"10.13039\/501100011744","name":"National University Health System, Singapore","doi-asserted-by":"crossref","award":["NMRC\/CG\/NUHS\/2010"],"award-info":[{"award-number":["NMRC\/CG\/NUHS\/2010"]}],"id":[{"id":"10.13039\/501100011744","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["NMRC\/CG\/NUHS\/2010"],"award-info":[{"award-number":["NMRC\/CG\/NUHS\/2010"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parkinson's Disease"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p><jats:italic>Aim<\/jats:italic>. This study sought to establish the discriminant validity of a rapid cognitive screen, that is, the National Institute of Neurological Disease and Stroke-Canadian Stroke Network (NINDS-CSN) 5-minute protocol, and compare its discriminant validity to the Montreal Cognitive Assessment (MoCA) and Mini Mental State Examination (MMSE) in detecting cognitive impairment (CI) in PD patients.<jats:italic>Methods<\/jats:italic>. One hundred and one PD patients were recruited from a movement disorders clinic in Singapore and they received the NINDS-CSN 5-minute protocol, MoCA, and MMSE. No cognitive impairment (NCI) was defined as Clinical Dementia Rating (CDR) = 0 and CI was defined as CDR \u2265 0.5.<jats:italic>Results<\/jats:italic>. Area under the receiver operating characteristic curve of NINDS-CSN 5-minute protocol was statistically equivalent to MoCA and larger than MMSE (0.86 versus 0.90,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.07<\/mml:mn><\/mml:math>; 0.86 versus 0.76,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.03<\/mml:mn><\/mml:math>). The sensitivity of NINDS-CSN 5-minute protocol (&lt;9) was statistically equivalent to MoCA (&lt;22) (0.77 versus 0.85,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.13<\/mml:mn><\/mml:math>) and superior to MMSE (&lt;24) (0.77 versus 0.52,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.01<\/mml:mn><\/mml:math>) in detecting CI, while the specificity of NINDS-CSN 5-minute protocol (&lt;9) was statistically equivalent to MoCA (&lt;22) and MMSE (&lt;24) (0.78 versus 0.88,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.34<\/mml:mn><\/mml:math>).<jats:italic>Conclusion<\/jats:italic>. The NINDS-CSN 5-minute protocol is time expeditious while remaining statistically equivalent to MoCA and superior to MMSE and therefore is suitable for rapid cognitive screening of CI in PD patients.<\/jats:p>","DOI":"10.1155\/2015\/348063","type":"journal-article","created":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T21:02:38Z","timestamp":1449090158000},"page":"1-6","source":"Crossref","is-referenced-by-count":4,"title":["Rapid Screening for Cognitive Impairment in Parkinson\u2019s Disease: A Pilot Study"],"prefix":"10.1155","volume":"2015","author":[{"given":"YanHong","family":"Dong","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Yong Loo Lin School of Medicine, National University Health System, BLK MD3 Level 4 #04-01, 16 Medical Drive, Singapore 117600"},{"name":"Department of Medicine, Yong Loo Lin School of Medicine, National University Health System, 1E, Level 10, NUHS Tower Block, Kent Ridge Road, Singapore 119228"},{"name":"CHeBA, NPI, Euroa Centre, Prince of Wales Hospital, Barker Street, Randwick, NSW 2031, Australia"},{"name":"Division of Neurology, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Way Inn","family":"Koay","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Yong Loo Lin School of Medicine, National University Health System, BLK MD3 Level 4 #04-01, 16 Medical Drive, Singapore 117600"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard Leong Litt","family":"Yeo","sequence":"additional","affiliation":[{"name":"Division of Neurology, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher Li-Hsian","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Yong Loo Lin School of Medicine, National University Health System, BLK MD3 Level 4 #04-01, 16 Medical Drive, Singapore 117600"},{"name":"Department of Medicine, Yong Loo Lin School of Medicine, National University Health System, 1E, Level 10, NUHS Tower Block, Kent Ridge Road, Singapore 119228"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Yong Loo Lin School of Medicine, National University Health System, BLK MD3 Level 4 #04-01, 16 Medical Drive, Singapore 117600"},{"name":"Department of Medicine, Yong Loo Lin School of Medicine, National University Health System, 1E, Level 10, NUHS Tower Block, Kent Ridge Road, Singapore 119228"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond Chee Seong","family":"Seet","sequence":"additional","affiliation":[{"name":"Department of Medicine, Yong Loo Lin School of Medicine, National University Health System, 1E, Level 10, NUHS Tower Block, Kent Ridge Road, Singapore 119228"},{"name":"Division of Neurology, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erle Chuen Hian","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Medicine, Yong Loo Lin School of Medicine, National University Health System, 1E, Level 10, NUHS Tower Block, Kent Ridge Road, Singapore 119228"},{"name":"Division of Neurology, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/s1474-4422(06)70471-9"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.60.3.387"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22384"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1177\/0891988712464823"},{"issue":"9","key":"5","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1161\/01.STR.0000237236.88823.47","volume":"37","year":"2006","journal-title":"Stroke"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1017\/s135561771200077x"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.112.673384"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.114.007253"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1017\/s1355617714000733"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.55.3.181"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2010.08.051"},{"issue":"11","key":"12","first-page":"2412","volume":"43","year":"1993","journal-title":"Neurology"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.2307\/2531595"},{"issue":"1","key":"14","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1002\/1097-0142(1950)3:1<32::AID-CNCR2820030106>3.0.CO;2-3","volume":"3","year":"1950","journal-title":"Cancer"}],"container-title":["Parkinson's 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