{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T17:43:06Z","timestamp":1764783786974,"version":"3.41.2"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,10,4]],"date-time":"2015-10-04T00:00:00Z","timestamp":1443916800000},"content-version":"vor","delay-in-days":276,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:p>The functions of genes involved in idiopathic portal hypertension (IPH) remain unidentified. \nThe present study was undertaken to identify the functions of genes expressed in blood\nsamples from patients with IPH through comprehensive analysis of gene expression using\nDNA microarrays. The data were compared with data from healthy individuals to explore the\nfunctions of genes showing increased or decreased expression in patients with IPH. In cluster\nanalysis, no dominant probe group was shown to differ between patients with IPH and healthy\ncontrols. In functional annotation analysis using the Database for Annotation Visualization\nand Integrated Discovery tool, clusters showing dysfunction in patients with IPH involved\ngene terms related to the immune system. Analysis using network\u2010based pathways revealed\ndecreased expression of adenosine deaminase, ectonucleoside triphosphate\ndiphosphohydrolase 4, ATP\u2010binding cassette, subfamily C, member 1, transforming growth\nfactor\u2010<jats:italic>\u03b2<\/jats:italic>, and prostaglandin E receptor 2; increased expression of cytochrome P450, family 4,\nsubfamily F, polypeptide 3, and glutathione peroxidase 3; and abnormalities in the immune\nsystem, nucleic acid metabolism, arachidonic acid\/leukotriene pathways, and biological\nprocesses. These results suggested that IPH involved compromised function of\nimmunocompetent cells and that such dysfunction may be associated with abnormalities in\nnucleic acid metabolism and arachidonic acid\/leukotriene\u2010related synthesis\/metabolism.<\/jats:p>","DOI":"10.1155\/2015\/349215","type":"journal-article","created":{"date-parts":[[2015,10,4]],"date-time":"2015-10-04T21:04:20Z","timestamp":1443992660000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Comprehensive Screening of Gene Function and Networks by DNA Microarray Analysis in Japanese Patients with Idiopathic Portal Hypertension"],"prefix":"10.1155","volume":"2015","author":[{"given":"Kohei","family":"Kotani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joji","family":"Kawabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyasu","family":"Morikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiko","family":"Akahoshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Hashizume","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susumu","family":"Shiomi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,10,4]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1078\/0344-0338-5710012"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-23207"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.17.s3.2.x"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2002.02764.x"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24422"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2002.02596.x"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.51.2.275"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2005.01151.x"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1006\/clin.1995.1073"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.1989.tb02488.x"},{"key":"e_1_2_8_11_2","first-page":"163","article-title":"Non-specific immunological abnormalities and association of autoimmune diseases in idiopathic portal hypertension. 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