{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T18:08:53Z","timestamp":1785002933116,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100000064","name":"National Center for Complementary and Alternative Medicine","doi-asserted-by":"publisher","award":["1RC1AT005836"],"award-info":[{"award-number":["1RC1AT005836"]}],"id":[{"id":"10.13039\/100000064","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Advances in Preventive Medicine"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>Statins reduce arterial stiffness but are also associated with mild muscle complaints. It is unclear whether individuals with muscle symptoms experience the same vascular benefit or whether statins affect striated and smooth muscle cells differently. We examined the effect of simvastatin treatment on arterial stiffness in patients who did versus those who did not exhibit muscle symptoms. Patients with a history of statin-related muscle complaints (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>115<\/mml:mn><\/mml:math>) completed an 8\u2009wk randomized, double-blind, cross-over trial of daily simvastatin 20\u2009mg and placebo. Serum lipids and pulse wave velocity (PWV) were assessed before and after each treatment. Muscle symptoms with daily simvastatin treatment were reported by 38 patients (33%). Compared to baseline, central PWV decreased (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:math>) following simvastatin treatment but not placebo (drug \u2217 time interaction:<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.047<\/mml:mn><\/mml:math>). Changes in central PWV with simvastatin treatment were not influenced by myalgia status or time on simvastatin (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>\u2265<\/mml:mo><mml:mn>0.15<\/mml:mn><\/mml:math>). Change in central PWV after simvastatin treatment was inversely correlated with age (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>r<\/mml:mi><mml:mo>=<\/mml:mo><mml:mo>-<\/mml:mo><mml:mn>0.207<\/mml:mn><\/mml:math>,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.030<\/mml:mn><\/mml:math>), suggesting that advancing age is associated with enhanced statin-mediated arterial destiffening. In patients with a history of statin-related muscle complaints, the development of myalgia with short-term simvastatin treatment did not attenuate the improvement in arterial stiffness.<\/jats:p>","DOI":"10.1155\/2015\/351059","type":"journal-article","created":{"date-parts":[[2015,7,15]],"date-time":"2015-07-15T17:05:52Z","timestamp":1436979952000},"page":"1-6","source":"Crossref","is-referenced-by-count":10,"title":["Effect of Simvastatin on Arterial Stiffness in Patients with Statin Myalgia"],"prefix":"10.1155","volume":"2015","author":[{"given":"Kevin D.","family":"Ballard","sequence":"first","affiliation":[{"name":"Division of Cardiology, Henry Low Heart Center, Hartford Hospital, Hartford, CT 06102, USA"},{"name":"Department of Kinesiology and Health, Miami University, Oxford, OH 45056, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay","family":"Lorson","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Henry Low Heart Center, Hartford Hospital, Hartford, CT 06102, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9367-4893","authenticated-orcid":true,"given":"C. Michael","family":"White","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Henry Low Heart Center, Hartford Hospital, Hartford, CT 06102, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul D.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Henry Low Heart Center, Hartford Hospital, Hartford, CT 06102, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth A.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Henry Low Heart Center, Hartford Hospital, Hartford, CT 06102, USA"},{"name":"Department of Health Sciences and Nursing, University of Hartford, West Hartford, CT 06117, 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