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Functional abnormalities of high\u2010density lipoprotein (HDL) could contribute to cardiovascular disease in chronic kidney disease patients. We measured a validated marker of HDL dysfunction, nitrated apolipoprotein A\u2010I, in kidney transplant recipients to test the hypothesis that a functioning kidney transplant reduces serum nitrated apoA\u2010I concentrations. <jats:italic>Methods<\/jats:italic>. Concentrations of nitrated apoA\u2010I and apoB were measured using indirect sandwich ELISA assays on sera collected from each transplant subject before transplantation and at 1, 3, and 12 months after transplantation. Patients were excluded if they have history of diabetes, treatment with lipid\u2010lowering medications or HIV protease inhibitors, prednisone dose &gt; 15\u2009mg\/day, nephrotic range proteinuria, serum creatinine &gt; 1.5\u2009mg\/dL, or active inflammatory disease. Sera from 18 transplanted patients were analyzed. Four subjects were excluded due to insufficient data. Twelve and eight patients had creatinine &lt; 1.5\u2009mg\/dL at 3 and 12 months after transplantation, respectively. <jats:italic>Results<\/jats:italic>. Nitrated apoA\u2010I was significantly reduced at 12 months after transplantation (<jats:italic>p<\/jats:italic> = 0.039). The decrease in apoA\u2010I nitration was associated with significant reduction in myeloperoxidase (MPO) activity (<jats:italic>p<\/jats:italic> = 0.047). In contrast to apoA\u2010I, nitrated apoB was not affected after kidney transplantation. <jats:italic>Conclusions<\/jats:italic>. Patients with well\u2010functioning grafts had significant reduction in nitrated apoA\u2010I 12 months after kidney transplantation. Further studies are needed in a large cohort to determine if nitrated apoA\u2010I can be used as a valuable marker for cardiovascular risk stratification in chronic kidney disease.<\/jats:p>","DOI":"10.1155\/2015\/352356","type":"journal-article","created":{"date-parts":[[2015,11,15]],"date-time":"2015-11-15T21:01:27Z","timestamp":1447621287000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Plasma Nitration of High\u2010Density and Low\u2010Density Lipoproteins in Chronic Kidney Disease Patients Receiving Kidney Transplants"],"prefix":"10.1155","volume":"2015","author":[{"given":"Ahmed","family":"Bakillah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fasika","family":"Tedla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Ayoub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devon","family":"John","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen J.","family":"Norin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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