{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T17:05:41Z","timestamp":1746810341867,"version":"3.40.5"},"reference-count":9,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61272182","61100028","61073063","61173030","61173029","2012AA011004","2011CB302200-G","61025007","61332014","NCET-11-0085","2012T50263","2011M500568","N130504001"],"award-info":[{"award-number":["61272182","61100028","61073063","61173030","61173029","2012AA011004","2011CB302200-G","61025007","61332014","NCET-11-0085","2012T50263","2011M500568","N130504001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61272182","61100028","61073063","61173030","61173029","2012AA011004","2011CB302200-G","61025007","61332014","NCET-11-0085","2012T50263","2011M500568","N130504001"],"award-info":[{"award-number":["61272182","61100028","61073063","61173030","61173029","2012AA011004","2011CB302200-G","61025007","61332014","NCET-11-0085","2012T50263","2011M500568","N130504001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61272182","61100028","61073063","61173030","61173029","2012AA011004","2011CB302200-G","61025007","61332014","NCET-11-0085","2012T50263","2011M500568","N130504001"],"award-info":[{"award-number":["61272182","61100028","61073063","61173030","61173029","2012AA011004","2011CB302200-G","61025007","61332014","NCET-11-0085","2012T50263","2011M500568","N130504001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61272182","61100028","61073063","61173030","61173029","2012AA011004","2011CB302200-G","61025007","61332014","NCET-11-0085","2012T50263","2011M500568","N130504001"],"award-info":[{"award-number":["61272182","61100028","61073063","61173030","61173029","2012AA011004","2011CB302200-G","61025007","61332014","NCET-11-0085","2012T50263","2011M500568","N130504001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61272182","61100028","61073063","61173030","61173029","2012AA011004","2011CB302200-G","61025007","61332014","NCET-11-0085","2012T50263","2011M500568","N130504001"],"award-info":[{"award-number":["61272182","61100028","61073063","61173030","61173029","2012AA011004","2011CB302200-G","61025007","61332014","NCET-11-0085","2012T50263","2011M500568","N130504001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012164","name":"National High-tech R&D Program (863 Program)","doi-asserted-by":"crossref","award":["61272182","61100028","61073063","61173030","61173029","2012AA011004","2011CB302200-G","61025007","61332014","NCET-11-0085","2012T50263","2011M500568","N130504001"],"award-info":[{"award-number":["61272182","61100028","61073063","61173030","61173029","2012AA011004","2011CB302200-G","61025007","61332014","NCET-11-0085","2012T50263","2011M500568","N130504001"]}],"id":[{"id":"10.13039\/501100012164","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China (973 Program)","doi-asserted-by":"crossref","award":["61272182","61100028","61073063","61173030","61173029","2012AA011004","2011CB302200-G","61025007","61332014","NCET-11-0085","2012T50263","2011M500568","N130504001"],"award-info":[{"award-number":["61272182","61100028","61073063","61173030","61173029","2012AA011004","2011CB302200-G","61025007","61332014","NCET-11-0085","2012T50263","2011M500568","N130504001"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100014219","name":"National Science Fund for Distinguished Young Scholars","doi-asserted-by":"crossref","award":["61272182","61100028","61073063","61173030","61173029","2012AA011004","2011CB302200-G","61025007","61332014","NCET-11-0085","2012T50263","2011M500568","N130504001"],"award-info":[{"award-number":["61272182","61100028","61073063","61173030","61173029","2012AA011004","2011CB302200-G","61025007","61332014","NCET-11-0085","2012T50263","2011M500568","N130504001"]}],"id":[{"id":"10.13039\/501100014219","id-type":"DOI","asserted-by":"crossref"}]},{"name":"State Key Program of National Natural Science of China","award":["61272182","61100028","61073063","61173030","61173029","2012AA011004","2011CB302200-G","61025007","61332014","NCET-11-0085","2012T50263","2011M500568","N130504001"],"award-info":[{"award-number":["61272182","61100028","61073063","61173030","61173029","2012AA011004","2011CB302200-G","61025007","61332014","NCET-11-0085","2012T50263","2011M500568","N130504001"]}]},{"name":"New Century Excellent Talents","award":["61272182","61100028","61073063","61173030","61173029","2012AA011004","2011CB302200-G","61025007","61332014","NCET-11-0085","2012T50263","2011M500568","N130504001"],"award-info":[{"award-number":["61272182","61100028","61073063","61173030","61173029","2012AA011004","2011CB302200-G","61025007","61332014","NCET-11-0085","2012T50263","2011M500568","N130504001"]}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["61272182","61100028","61073063","61173030","61173029","2012AA011004","2011CB302200-G","61025007","61332014","NCET-11-0085","2012T50263","2011M500568","N130504001"],"award-info":[{"award-number":["61272182","61100028","61073063","61173030","61173029","2012AA011004","2011CB302200-G","61025007","61332014","NCET-11-0085","2012T50263","2011M500568","N130504001"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["61272182","61100028","61073063","61173030","61173029","2012AA011004","2011CB302200-G","61025007","61332014","NCET-11-0085","2012T50263","2011M500568","N130504001"],"award-info":[{"award-number":["61272182","61100028","61073063","61173030","61173029","2012AA011004","2011CB302200-G","61025007","61332014","NCET-11-0085","2012T50263","2011M500568","N130504001"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"crossref","award":["61272182","61100028","61073063","61173030","61173029","2012AA011004","2011CB302200-G","61025007","61332014","NCET-11-0085","2012T50263","2011M500568","N130504001"],"award-info":[{"award-number":["61272182","61100028","61073063","61173030","61173029","2012AA011004","2011CB302200-G","61025007","61332014","NCET-11-0085","2012T50263","2011M500568","N130504001"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computational and Mathematical Methods in Medicine"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>Diagnostic genes are usually used to distinguish different disease phenotypes. Most existing methods for diagnostic genes finding are based on either the individual or combinatorial discriminative power of gene(s). However, they both ignore the common expression trends among genes. In this paper, we devise a novel sequence rule, namely, top-<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>k<\/mml:mi><\/mml:mrow><\/mml:math>irreducible covering contrast sequence rules (Top<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mi>k<\/mml:mi><\/mml:mrow><\/mml:math>IRs for short), which helps to build a sample classifier of high accuracy. Furthermore, we propose an algorithm called MineTop<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mrow><mml:mi>k<\/mml:mi><\/mml:mrow><\/mml:math>IRs to efficiently discover Top<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mrow><mml:mi>k<\/mml:mi><\/mml:mrow><\/mml:math>IRs. Extensive experiments conducted on synthetic and real datasets show that MineTop<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mrow><mml:mi>k<\/mml:mi><\/mml:mrow><\/mml:math>IRs is significantly faster than the previous methods and is of a higher classification accuracy. Additionally, many diagnostic genes discovered provide a new insight into disease diagnosis.<\/jats:p>","DOI":"10.1155\/2015\/353146","type":"journal-article","created":{"date-parts":[[2015,3,10]],"date-time":"2015-03-10T21:33:25Z","timestamp":1426023205000},"page":"1-11","source":"Crossref","is-referenced-by-count":1,"title":["Finding Top-<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>k<\/mml:mi><\/mml:mrow><\/mml:math>Covering Irreducible Contrast Sequence Rules for Disease Diagnosis"],"prefix":"10.1155","volume":"2015","author":[{"given":"Yuhai","family":"Zhao","sequence":"first","affiliation":[{"name":"College of Information Science and Engineering, Northeastern University, Shenyang, Liaoning 110819, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Li","sequence":"additional","affiliation":[{"name":"College of Information Science and Engineering, Northeastern University, Shenyang, Liaoning 110819, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7995-8590","authenticated-orcid":true,"given":"Ying","family":"Yin","sequence":"additional","affiliation":[{"name":"College of Information Science and Engineering, Northeastern University, Shenyang, Liaoning 110819, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7089-1302","authenticated-orcid":true,"given":"Gang","family":"Sheng","sequence":"additional","affiliation":[{"name":"Software Center, Northeastern University, Shenyang, Liaoning 110004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"doi-asserted-by":"publisher","key":"1","DOI":"10.1126\/science.286.5439.531"},{"doi-asserted-by":"publisher","key":"2","DOI":"10.1038\/nm0102-68"},{"doi-asserted-by":"publisher","key":"3","DOI":"10.1056\/nejm200102223440801"},{"doi-asserted-by":"publisher","key":"4","DOI":"10.1016\/j.neucom.2009.11.009"},{"doi-asserted-by":"publisher","key":"6","DOI":"10.1007\/11567752_10"},{"doi-asserted-by":"publisher","key":"7","DOI":"10.1093\/bioinformatics\/btp713"},{"doi-asserted-by":"publisher","key":"13","DOI":"10.1109\/TKDE.2010.207"},{"issue":"11","key":"15","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1101\/gr.190001","volume":"11","year":"2001","journal-title":"Genome Research"},{"doi-asserted-by":"publisher","key":"16","DOI":"10.1093\/bioinformatics\/btg179"}],"container-title":["Computational and Mathematical Methods in Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2015\/353146.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2015\/353146.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2015\/353146.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T01:07:28Z","timestamp":1589504848000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/cmmm\/2015\/353146\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":9,"alternative-id":["353146","353146"],"URL":"https:\/\/doi.org\/10.1155\/2015\/353146","relation":{},"ISSN":["1748-670X","1748-6718"],"issn-type":[{"type":"print","value":"1748-670X"},{"type":"electronic","value":"1748-6718"}],"subject":[],"published":{"date-parts":[[2015]]}}}