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To expand upon the role of iguratimod (T\u2010614) in the treatment of rheumatoid arthritis (RA), we investigated whether the Th1, Th17, follicular helper T cells (Tfh), and regulatory T cells (Treg) imbalance could be reversed by iguratimod and the clinical implications of this reversal. <jats:italic>Methods<\/jats:italic>. In this trial, 74 patients were randomized into iguratimod\u2010treated (group A) and control (broup B) group for a 24\u2010week treatment period. In the subsequent 28 weeks, both groups were given iguratimod. Frequencies of Th1, Th17, Tfh, and Treg were quantified using flow cytometry, and serum cytokines were detected by enzyme\u2010linked immunosorbent assay. mRNA expression of cytokines and transcriptional factor were quantified by RT\u2010PCR. The composite Disease Activity Score, erythrocyte sedimentation rate, and C\u2010reactive protein were assessed at each visit. <jats:italic>Result<\/jats:italic>. The clinical scores demonstrated effective suppression of disease after treatment with iguratimod. In addition, iguratimod downregulated Th1, Th17\u2010type response and upregulated Treg. 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