{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:21:47Z","timestamp":1761513707123,"version":"3.37.3"},"reference-count":24,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81072794","2008GG2NS02011"],"award-info":[{"award-number":["81072794","2008GG2NS02011"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003091","name":"Shandong Province","doi-asserted-by":"publisher","award":["81072794","2008GG2NS02011"],"award-info":[{"award-number":["81072794","2008GG2NS02011"]}],"id":[{"id":"10.13039\/501100003091","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>Endothelial dysfunction and low-grade inflammation are closely associated with hypertension and other cardiovascular diseases. The combination of<jats:italic>Uncaria (U)<\/jats:italic>and<jats:italic>Semen Raphani (R)<\/jats:italic>is common in traditional Chinese medicine for the treatment of hypertension and heart diseases. We aimed to investigate the therapeutic effect of the combination of<jats:italic>Uncaria<\/jats:italic>and<jats:italic>Semen Raphani<\/jats:italic>on spontaneously hypertensive rats (SHRs), and valsartan was used as a positive control. In the present study, all extracts decreased systolic pressure, diastolic pressure, and mean arterial pressure.<jats:italic>U<\/jats:italic>alone showed antihypertensive efficacy and effectively decreased CECs count, while<jats:italic>R<\/jats:italic>alone showed efficacy in relieving inflammatory level. The combination of<jats:italic>U<\/jats:italic>and<jats:italic>R<\/jats:italic>showed enhanced effectiveness at lowering activated CECs and improving endothelial integrity of thoracic aorta and mesenteric artery and normalized the level of plasma biomarkers of endothelial damage. The combination of<jats:italic>U<\/jats:italic>and<jats:italic>R<\/jats:italic>decreased the mRNA level of VCAM-1, Sel-L, TFPI, and Sel-P, while it elevated mRNA expression of FGF-1 and THBD of the thoracic aorta, which may be, at least in part, involved in the mechanism of protective effect on hypertensive endothelial injury.<\/jats:p>","DOI":"10.1155\/2015\/358352","type":"journal-article","created":{"date-parts":[[2015,10,12]],"date-time":"2015-10-12T19:15:04Z","timestamp":1444677304000},"page":"1-11","source":"Crossref","is-referenced-by-count":8,"title":["Enhanced Protective Effect of the Combination of<i>Uncaria<\/i>and<i>Semen Raphani<\/i>on Vascular Endothelium in Spontaneously Hypertensive Rats"],"prefix":"10.1155","volume":"2015","author":[{"given":"Yun-lun","family":"Li","sequence":"first","affiliation":[{"name":"Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250011, 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