{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T23:30:50Z","timestamp":1787614250148,"version":"build-2736575974"},"reference-count":43,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Fujian Provincial Natural Science Foundation of China","award":["2014J01330"],"award-info":[{"award-number":["2014J01330"]}]},{"name":"Fujian Provincial Natural Science Foundation of China","award":["2012Y0032"],"award-info":[{"award-number":["2012Y0032"]}]},{"name":"Key Technology Plan Program of Fujian Provincial Science and Technology Department of China","award":["2014J01330"],"award-info":[{"award-number":["2014J01330"]}]},{"name":"Key Technology Plan Program of Fujian Provincial Science and Technology Department of China","award":["2012Y0032"],"award-info":[{"award-number":["2012Y0032"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>The present study aimed to assess the protective effects of aqueous extract from<jats:italic>Morinda officinalis F. C. How<\/jats:italic>on microwave-induced reproductive impairment in male rats. Microwave exposure injury was induced by exposure of 900\u2009MHz microwaves at 218\u2009<jats:italic>\u03bc<\/jats:italic>m\/cm<jats:sup>2<\/jats:sup>radiation densities, 24 hours\/day for 10 days. Male Sprague-Dawley rats were randomized to: normal control, microwave exposure model, or water layer or ethyl acetate layer of aqueous extract 40\u2009g\/kg treatment groups. After 2 weeks of treatment, sexual performance, serum levels of gonadotrophin-releasing hormone (GnRH), luteinizing hormone (LH), follicle-stimulating hormone (FSH) or testosterone, morphological analysis of testis and epididymis, and GnRH protein expression in the hypothalamus were measured. Pretreatment with water layer of aqueous extract 40\u2009g\/kg significantly improved sexual performance, increased serum testosterone level, and decreased LH and GnRH level compared with microwave exposed model rats (all<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>). Water layer of aqueous extract treatment significantly increased seminiferous cell or sperm number in testis and epididymis. Protein expression of GnRH in the hypothalamus significantly decreased in the water layer of aqueous extract treated group (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>). Ethyl acetate layer of aqueous extract did not show obvious effects on the measured parameters. These findings suggest that water layer of aqueous extract 40\u2009g\/kg ameliorates microwave-reduced reproductive impairment.<\/jats:p>","DOI":"10.1155\/2015\/360730","type":"journal-article","created":{"date-parts":[[2015,9,9]],"date-time":"2015-09-09T07:46:34Z","timestamp":1441784794000},"page":"1-10","source":"Crossref","is-referenced-by-count":18,"title":["Effect of Aqueous Extract from<i>Morinda officinalis F. C. How<\/i>on Microwave-Induced Hypothalamic-Pituitary-Testis Axis Impairment in Male Sprague-Dawley Rats"],"prefix":"10.1155","volume":"2015","author":[{"given":"Bin","family":"Song","sequence":"first","affiliation":[{"name":"Department of Human Anatomy and Histoembryology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou 350108, China"},{"name":"Key Laboratory of Brain Aging and Neurodegenerative Diseases of Fujian Provincial Universities and Colleges, Fuzhou 350108, China"},{"name":"Research Center for Neuroscience, Fujian Medical University, Fuzhou 350108, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengjuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery, First Ailiated Hospital of Xiamen University, Xiamen 361003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy and 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