{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T06:56:00Z","timestamp":1763535360579,"version":"3.37.3"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"National Science and Technology Major Project of the Ministry of Science and Technology of China","award":["2012ZX09301002-001-015","2012ZX10004501-004-001"],"award-info":[{"award-number":["2012ZX09301002-001-015","2012ZX10004501-004-001"]}]},{"name":"National Science and Technology Major Project of the Ministry of Science and Technology of China","award":["2012ZX09301002-001-015","2012ZX10004501-004-001"],"award-info":[{"award-number":["2012ZX09301002-001-015","2012ZX10004501-004-001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>Influenza is still a serious threat to human health with significant morbidity and mortality. The emergence of drug-resistant influenza viruses poses a great challenge to existing antiviral drugs. Traditional Chinese medicines (TCMs) may be an alternative to overcome the challenge. Here, 10 oral proprietary Chinese medicines were selected to evaluate their anti-influenza activities. These drugs exhibit potent inhibitory effects against influenza A H1N1, influenza A H3N2, and influenza B virus. Importantly, they demonstrate potent antiviral activities against drug-resistant strains. In the study of mechanisms, we found that Xiaoqinglong mixture could increase antiviral interferon production by activating p38 MAPK, JNK\/SAPK pathway, and relative nuclear transcription factors. Lastly, our studies also indicate that some of these medicines show inhibitory activities against EV71 and CVB strains. In conclusion, the 10 traditional Chinese medicines, as kind of compound combination medicines, show broad-spectrum antiviral activities, possibly also including inhibitory activities against strains resistant to available antiviral drugs.<\/jats:p>","DOI":"10.1155\/2015\/367250","type":"journal-article","created":{"date-parts":[[2015,10,8]],"date-time":"2015-10-08T17:09:51Z","timestamp":1444324191000},"page":"1-9","source":"Crossref","is-referenced-by-count":12,"title":["Antiviral Activities of Several Oral Traditional Chinese Medicines against Influenza Viruses"],"prefix":"10.1155","volume":"2015","author":[{"given":"Lin-Lin","family":"Ma","sequence":"first","affiliation":[{"name":"Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miao","family":"Ge","sequence":"additional","affiliation":[{"name":"Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-Qiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Qiu","family":"Yin","sequence":"additional","affiliation":[{"name":"Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1138-2943","authenticated-orcid":true,"given":"Jian-Dong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China"},{"name":"Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Huan","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.5546\/aap.2013.e10"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2014.07.012"},{"issue":"5","key":"3","first-page":"550","volume":"28","year":"2012","journal-title":"Chinese Journal of Biotechnology"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-010-0025-y"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1111\/irv.12176"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiu447"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2012.03.021"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.3201\/eid2101.141006"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61209-X"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.3978\/j.issn.2072-1439.2011.11.04"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/s0254-6272(13)60004-7"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-155-4-201108160-00005"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.2174\/1871526514666140827102154"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.1892"},{"issue":"1","key":"15","first-page":"77","volume":"19","year":"2005","journal-title":"Chinese Journal of Experimental and Clinical Virology"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2005.25.749"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.5.3252"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/s0163-7258(03)00016-0"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.3109\/1040841X.2011.580723"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1007\/s00284-013-0498-z"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422x-10-28"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgr.2014.04.003"},{"issue":"9","key":"23","first-page":"1443","volume":"40","year":"2009","journal-title":"Chinese Traditional and Herbal Drugs"},{"issue":"5","key":"24","first-page":"388","volume":"32","year":"2001","journal-title":"Journal of China Pharmaceutical University"},{"issue":"5","key":"25","first-page":"383","volume":"25","year":"2010","journal-title":"Chinese Journal of Practical Pediatrics"},{"issue":"6","key":"26","first-page":"81","volume":"18","year":"2011","journal-title":"Chinese Journal of Information on TCM"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/750803"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1016\/0166-3542(94)00062-d"},{"issue":"20","key":"29","first-page":"1715","volume":"31","year":"2006","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"issue":"1","key":"30","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S2225-4110(16)30070-0","volume":"2","year":"2012","journal-title":"Journal of Traditional and Complementary Medicine"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.3382\/ps.2013-03772"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2015.02.026"},{"issue":"6","key":"33","first-page":"555","volume":"18","year":"2015","journal-title":"Iranian Journal of Basic Medical Sciences"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2013.1227"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1038\/nri3665"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.3947\/ic.2013.45.1.11"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2015\/367250.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2015\/367250.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2015\/367250.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T17:00:04Z","timestamp":1498237204000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/ecam\/2015\/367250\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":36,"alternative-id":["367250","367250"],"URL":"https:\/\/doi.org\/10.1155\/2015\/367250","relation":{},"ISSN":["1741-427X","1741-4288"],"issn-type":[{"type":"print","value":"1741-427X"},{"type":"electronic","value":"1741-4288"}],"subject":[],"published":{"date-parts":[[2015]]}}}